729-46-4

中文名称 4,4'-(dithiodicarbonothioyl)dimorpholine

英文名称 4,4'-(dithiodicarbonothioyl)dimorpholine

CAS 729-46-4

分子式 C10H16N2O2S4

分子量 324.51

MOL 文件 729-46-4.mol

更新日期 2023/03/20 15:41:27

729-46-4 结构式

基本信息物理化学性质图谱信息 4,4'-(dithiodicarbonothioyl)dimorpholine价格(试剂级) 常见问题列表

基本信息

中文别名

化合物JX06

英文别名

JX 06
Bis(morpholinothiocarbonyl) disulfide
Bis(morpholinocarbonothioyl) persulfide
4,4'-(dithiodicarbonothioyl)dimorpholine
Morpholine, 4,4-(dithiodicarbonothioyl)bis-

物理化学性质

熔点136-137 °C

沸点466.3±55.0 °C(Predicted)

密度1.4302 (rough estimate)

折射率1.5650 (estimate)

储存条件-20°C储存

溶解度溶于二甲基亚砜

酸度系数(pKa)0.58±0.20(Predicted)

形态固体

颜色White to off-white

EPA化学物质信息Morpholine, 4,4'-(dithiodicarbonothioyl)bis- (729-46-4)

图谱信息

4,4'-(dithiodicarbonothioyl)dimorpholine(729-46-4)核磁图(¹HNMR)

4,4'-(dithiodicarbonothioyl)dimorpholine价格(试剂级)

报价日期	产品编号	产品名称	CAS号	包装	价格
2024/04/30	HY-19564	4,4'-(dithiodicarbonothioyl)dimorpholine JX06	729-46-4	5mg	500元
2024/04/30	HY-19564	4,4'-(dithiodicarbonothioyl)dimorpholine JX06	729-46-4	10mM * 1mLin DMSO	550元
2024/04/30	HY-19564	4,4'-(dithiodicarbonothioyl)dimorpholine JX06	729-46-4	10mg	800元

常见问题列表

生物活性

JX06 是一种细胞中的 PDK1 的选择性共价抑制剂。JX06 可剂量依赖性地抑制PDK1、PDK2和PDK3，对应的IC50值分别为0.049 μM、0.101 μM 和 0.313 μM。

靶点

Target	Value
PDK1 (Cell-free assay)	0.049 μM
PDK2 (Cell-free assay)	0.101 μM
PDK3 (Cell-free assay)	0.313 μM

体外研究

JX06 barely shows inhibitory activity against PDK4 at a concentration of 10 μM.
JX06 (1-10 μM; 48 hours) induces cell apoptosis in cancer cells with high ECAR/OCR.
JX06 (0-0.6 μM; 72 hours) dose-dependently suppresses the growth of A549 cells.
JX06 (0.1-10 μM; 6-24 hours) inhibits PDHA1 phosphorylation in A549 cells in a time- and dose-dependent manner.
JX06 (1-10 μM) increases glucose uptake and intracellular ATP level and reduces aerobic glycolysis determined by the lactate production in A549 cells.
JX06 (1-10 μM; 24 hours) induces ROS generation in cancer cells with high extracellular acidification rate (ECAR)/ oxygen consumption rate (OCR) .

Apoptosis Analysis

Cell Line:	A549, EBC-1, HT-29 and H460 cells
Concentration:	0, 1, 3, 10 μM
Incubation Time:	48 hours
Result:	Induces cell apoptosis in A549 and EBC-1 cells.

Cell Viability Assay

Cell Line:	A549 cells
Concentration:	0, 0.2, 0.4, 0.6 μM
Incubation Time:	72 hours
Result:	Inhibits the viability of A549 cells in a dose dependent manner.

Western Blot Analysis

Cell Line:	A549 cells
Concentration:	0, 0.1, 0.3, 1, 3, 10 μM
Incubation Time:	0, 6, 12, 24 hours
Result:	Decreased PDHA1 phosphorylation at both serine 293 and serine 232 (S293 and S232) in a time- and dose-dependent manner.

体内研究

JX06 (40-80 mg/kg; i.p. for 21 days) inhibits tumor growth in vivo.

Animal Model:	A549 subcutaneous xenograft mice
Dosage:	40, 80 mg/kg
Administration:	I.p. injections for 21 days
Result:	Reduced tumor weights and 67.5% tumor volume at the dose of 80 mg/kg compared with the vehicle control. Well tolerated at the administration dose.