732973-87-4
中文名称
N-(4-氯苯基)-4-(1H-吲哚-4-基)哌嗪-1-甲酰胺
英文名称
GOT1 inhibitor 2c
CAS
732973-87-4
分子式
C19H19ClN4O
分子量
354.83
MOL 文件
732973-87-4.mol
更新日期
2024/06/17 15:44:21
732973-87-4 结构式
基本信息
中文别名
化合物GOT1 INHIBITOR-1N-(4-氯苯基)-4-(1H-吲哚-4-基)哌嗪-1-甲酰胺
英文别名
GOT1 inhibitor-1GOT1 inhibitor 2c
N-(4-chlorophenyl)-4-(1H-indol-4-yl)piperazine-1-carboxamide
GOT1 inhibitor1,inhibit,GOT-1 inhibitor-1,glutamate-oxaloacetate transaminase 1,Cancer,Pancreatic,GOT1,metabolism,?Aspartate aminotransferase-1,ductal,Inhibitor,GOT1 inhibitor 1,PDAC,adenocarcinoma,GOT1 inhibitor-1
常见问题列表
生物活性
GOT1 inhibitor-1 (compound 2c) 是一种戊酸衍生物，是一种新型的、有效的、非共价的谷氨酸草酰乙酸转氨酶 1 (GOT1) 抑制剂，IC50 为 8.2 uM。 GOT1 inhibitor-1 可用于胰腺导管腺癌 (PDAC) 的研究。体外研究
PDAC tumors are dependent upon a metabolic pathway involving aspartate aminotransferase 1 (glutamate-oxaloacetate transaminase 1 (GOT1)), for the maintenance of redox homeostasis and sustained proliferation. Small molecule inhibitors targeting this metabolic pathway may provide a novel way for cancer research. In the MDH coupled GOT1 enzymatic assay, GOT1 inhibitor-1 shows an inhibitory effect on GOT1 activity with an IC 50 value of 8.2 uM.