73904-93-5
中文名称
RUTAEVINEXIC ACID
CAS
73904-93-5
分子式
C26H30O10
分子量
502.51
73904-93-5 结构式
基本信息
英文别名
Isolimonexin21=>23-trilacton
Limonexylic acid
IsoliMonexic acid
Rutaevinexic acid
(17R,23Xi)-1alpha,4
14,15beta-Diepoxy-17,19,23,23-tetrahydroxy-4,4,8-trimethyl-7-oxo-3,4
16,17-diseco-24-nor-5alpha,13alpha,14beta-chol-20(22)-en-3,16,21-trisaeure-3=>19
11H,13H-Oxireno[d]pyrano[4',3':3,3a]isobenzofuro[5,4-f][2]benzopyran-4,6,13(2H,5aH)-trione, 8-(2,5-dihydro-5-hydroxy-2-oxo-3-furanyl)decahydro-2,2,4a,8a-tetramethyl-, (2aR,4aR,4bR,5aS,8R,8aS,10aR,10bR,14aS)-
常见问题列表
生物活性
Isolimonexic acid 是从柠檬种子中分离得到的一种类柠檬酸，具有抗癌和抗芳香化酶 (anti-aromatase) (IC50=25.60 μM) 特性。靶点
IC50: 25.60 μM (aromatase)
体外研究
Isolimonexic acid (200 μM; 72 hours) exhibits cytotoxicity on MCF-7 cells and shows no cytotoxicity against the MDA-MB-231 cell lines.Isolimonexic acid (50 μg/ml; 48, 96 and 144 hours) exhibits cell growth inhibition of Panc-28 cells in a time-dependent manner.And it percent inhibition comparison to control cells are 21%, 68%, and 90.58% at 48, 72, and 144 h, respectively.