74764-40-2
中文名称
盐酸苄普地尔
英文名称
Bepridil hydrochloride
CAS
74764-40-2
分子式
C24H37ClN2O2
分子量
421.016
MOL 文件
74764-40-2.mol
更新日期
2024/08/11 23:00:16
74764-40-2 结构式
基本信息
中文别名
盐酸苄普地尔苄普地尔盐酸盐
苄普地尔盐酸盐水合物
1-异丁氧基-2-吡咯烷基-3-(N-苄基苯胺基)丙烷盐酸盐
化合物 BEPRIDIL HYDROCHLORIDE HYDRATE
英文别名
angoprilUnii-4W2p15D93m
Bepridil hydrochloride
UEECHQPWQHYEDE-UHFFFAOYSA-N
Bepridil hydrochloride salt
Bepridil hydrochloride hydrate
Bepridil hydrochloride USP/EP/BP
l)-,monohydrochloride,monohydrate
1-Isobutoxy-2-pyrrolidino-3-(N-benzylanilino)propane hydrochloride
N-Benzyl-N-(3-isobutoxy-2-pyrrolidin-1-yl-propyl)anilinehydrochloride
所属类别
原料药：防治心绞痛药物理化学性质
熔点91 ±2°
储存条件Desiccate at RT
溶解度Soluble in DMSO (up to 25 mg/ml) or ethanol (up to 25 mg/ml)
形态powder
颜色white
稳定性Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
安全数据
警示词危险
危险性描述H317-H332-H334
WGK Germany2
RTECS号UY1162000
毒性LD50 in mice (mg/kg): 1955 orally, 23.5 i.v. (Mauvernay, 1978)
常见问题列表
生物活性
Bepridil hydrochloride是一种抗心绞痛的药物，是钙离子通道（calcium channel）阻滞剂。它能阻止多种其他离子通道，包括钠离子和钾离子通道。靶点
|
Ca 2+
|
体外研究
Bepridil hydrochloride hydrate blockades of Ca
2+
-dependent action potentials in vascular smooth muscle of dog coronary artery.
Bepridil hydrochloride hydrate blocks Ca currents and Na currents with IC
50
s of 0.5 μM and 30 μM, respectively in cultured ventricular cells.
Bepridil hydrochloride hydrate decreases I
Ks
under blockade of I
Kr
with E4031 (5 μM), in a concentration-dependent manner.
体内研究
Bepridil hydrochloride hydrate exhibits a half-life of averages 33±15 hours after single-dose administration.