75219-46-4
75219-46-4 结构式
基本信息
中文别名
化合物 T14344 英文别名
KM-2210bestrabucil
Bestrabucil (KM2210)
Estra-1,3,5(10)-triene-3,17β-diol 3-benzoate 17-[4-[4-[bis(2-chloroethyl)amino]phenyl]-1-oxobutoxy]acetate
Estra-1,3,5(10)-triene-3,17-diol (17β)-, 3-benzoate 17-[2-[4-[4-[bis(2-chloroethyl)amino]phenyl]-1-oxobutoxy]acetate]
物理化学性质
沸点804.3±65.0 °C(Predicted)
密度1.1424 (rough estimate)
折射率1.7350 (estimate)
储存条件-20°C储存
溶解度溶于二甲基亚砜
酸度系数(pKa)4.65±0.50(Predicted)
形态Solid
颜色Crystals
常见问题列表
生物活性
Atrimustine 是苯丁酸氮芥与 β-雌二醇苯甲酸酯的结合物，具有抗肿瘤活性。体外研究
Atrimustine (Bestrabucil), a conjugate of chlorambucil and β-estradiol benzoate, has high affinity for tumor cells and enhances the antitumor activity of chlorambucil.The effect of Atrimustine (Bestrabucil), a benzoate of an estradiol-chlorambucil conjugate, is examined on the production of growth factor(s) by Shionogi carcinoma 115 (SC-115) cells, an androgen-responsive cultured cancer cell line. At Atrimustine concentrations of 100 nM-10 μM, concentration-dependent inhibition of growth factor production by SC-115 cells can be demonstrated by 3 H-thymidine uptake assay.