75704-24-4
中文名称
WAY 161503盐酸盐
英文名称
8,9-DICHLORO-2,3,4,4A-TETRAHYDRO-1H-PYRAZINO[1,2-A]QUINOXALIN-5(6H)-ONE HYDROCHLORIDE
CAS
75704-24-4
分子式
C11H11Cl2N3O
分子量
272.13
MOL 文件
75704-24-4.mol
75704-24-4 结构式
基本信息
中文别名
WAY 161503盐酸盐 英文别名
WAY 161503WAY 161503 HYDROCHLORIDE
1H-Pyrazino[1,2-a]quinoxalin-5(6H)-one, 8,9-dichloro-2,3,4,4a-tetrahydro-
8,9-DICHLORO-2,3,4,4A-TETRAHYDRO-1H-PYRAZINO[1,2-A]QUINOXALIN-5(6H)-ONE HYDROCHLORIDE
所属类别
生物化工：激动剂抑制剂物理化学性质
沸点513.9±50.0 °C(Predicted)
密度1.54±0.1 g/cm3(Predicted)
储存条件Desiccate at RT
溶解度DMF: 30 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 25 mg/ml; Ethanol: 1 mg/ml
酸度系数(pKa)12.09±0.20(Predicted)
形态结晶固体
颜色Off-white to light yellow
常见问题列表
用途
WAY 161503盐酸盐是一种有效的、选择性的、高亲和力的 5-HT2C 受体激动剂，具有抗肥胖和抗抑郁的作用。
靶点
|
5-HT 2C Receptor 4 nM (Ki) |
5-HT 2C Receptor 12 nM (EC 50 ) |
体内研究
(Rac)-WAY-161503 (3-30 mg/kg; intraperitoneal injection; male C57BL/6J mice) treatment dose-dependently decreases locomotor activity, an effect that is blocked by the 5-HT 2C/2B antagonist SER-082. Additionally, the decreased locomotor activity produced by 10 mg/kg DOI is potentiated in the 5-HT 2A KO mice.
| Animal Model: | Male C57BL/6J mice with hallucinogen 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) |
| Dosage: | 3 mg/kg, 10 mg/kg, 30 mg/kg |
| Administration: | Intraperitoneal injection |
| Result: | Dose-dependently decreased locomotor activity, an effect that was blocked by the 5-HT 2C/2B antagonist SER-082. |