76-80-2
76-80-2 结构式
基本信息
中文别名
灰叶素灰叶草素, 羟基鱼藤素
英文别名
Deguelinol IIsotephrosin
Hydroxydeguelin
Tephrosin (synthetic)
(-)-TEPHROSIN USP/EP/BP
Tephrosin >=95% (LC/MS-ELSD)
13,13a-Dihydro-7a-hydroxy-9,10-dimethoxy-3,3-dimethyl-3H-bis[1]benzopyrano[3,4-b:6',5'-e]pyran-7(7aH)-one
3H-Bis[1]benzopyrano[3,4-b:6',5'-e]pyran-7- (7aH)-one,13,13a-dihydro-7a-hydroxy-9,10- dimethoxy-3,3-dimethyl-,(7aR,13aR)-
所属类别
生物化工：中草药成分物理化学性质
熔点198° (218-220°)
沸点450.42°C (rough estimate)
密度1.2284 (rough estimate)
折射率1.5300 (estimate)
储存条件-20°C
溶解度Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
酸度系数(pKa)10.47±0.40(Predicted)
形态Cryst.
颜色White to off-white
常见问题列表
生物活性
Tephrosin 是一种天然类胡萝卜素，具有较强的抗肿瘤活性。Tephrosin 通过诱导受体内化来诱导 EGFR 和 ErbB2 的降解。体外研究
Treatment of HT-29 cells with tephrosin (0-10μM) inhibits both the ligand-induced and constitutive phosphorylation of EGFR, ErbB2 and ErbB3, and concomitantly suppresses the activation of the downstream signaling molecules such as Akt and Erk1/2 mitogen-activated protein kinase (MAPK) .