76150-91-9
中文名称
TCPOBOP
英文名称
TCPOBOP
CAS
76150-91-9
分子式
C16H8Cl4N2O2
分子量
402.06
MOL 文件
76150-91-9.mol
更新日期
2024/07/29 15:51:16
76150-91-9 结构式
基本信息
中文别名
化合物TCPOBOP1,4-双((3,5-二氯吡啶-2-基)氧基)苯
英文别名
TCPOBOP3,3',5,5'-TETRACHLORIDE-BPB
TCPOBOP - CAS 76150-91-9 - Calbiochem
1,4-Bis(3,5-dichloro-2-pyridyloxy)benzene
1,4-BIS[2-(3,5-DICHLOROPYRIDYLOXY)]BENZENE
1,4-Bis(3,5-Dichloro-2-pyridinyloxy)benzene
3,3',5,5'-TETRACHLORIDE-BISPYRIDYLOXYBENZENE
1,4-Bis[(3,5-dichloropyridin-2-yl)oxy]benzene
3,3′,5,5′-Tetrachloro-1,4-bis(pyridyloxy)benzene
2,2'-(p-Phenylenebisoxy)bis(3,5-dichloropyridine)
物理化学性质
沸点444.8±45.0 °C(Predicted)
密度1.518±0.06 g/cm3(Predicted)
储存条件2-8°C
溶解度DMSO: >10 mg/mL
酸度系数(pKa)-0.52±0.10(Predicted)
形态solid
颜色white
稳定性Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 week.
常见问题列表
生物活性
TCPOBOP 是一种组成型雄甾烷受体 (CAR) 激动剂,可诱导强健的肝细胞增殖和肝肿大,无任何肝损伤或组织缺失。TCPOBOP 通过改变 Bcl-2 蛋白减弱 Fas 诱导的小鼠肝损伤。靶点
Bcl-2
|
体内研究
TCPOBOP (oral; 3 mg/kg; 1-5 days) remarkable increases Liver weight to body weight in LW/BW ratio at 48 hours.
Animal Model: | MET fl/fl : Tam-Cre +/+ mice with a targeted deletion for exon 16 with MET KO |
Dosage: | 3 mg/kg |
Administration: | Oral; 1, 2, 5 days |
Result: | Increased Liver weight to body weight. |