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76706-55-3

中文名称 粘噻唑
英文名称 MYXOTHIAZOL
CAS 76706-55-3
分子式 C25H33N3O3S2
分子量 487.68
MOL 文件 76706-55-3.mol
更新日期 2023/03/20 15:41:19
76706-55-3 结构式 76706-55-3 结构式

基本信息

中文别名
粘噻唑
英文别名
Myxothiazo
MYXOTHIAZOL
5-dimethoxy-4-methyl-
myxothiazolfrommyxobacterium
MYXOTHIAZOL, VIAL WITH 10 MG*
MYXOTHIAZOL FROM MYXOBACTERIUM 95%
MYXOTHIAZOL, FROM MYXOCOCCUS FULVUS
myxothiazol from myxobacterium*myxococcus fulvus
7-(2’-(1,6-dimethyl-2,4-heptadienyl)(2,4’-bithiazol)-4-yl)-6-heptadienamide
2,6-Heptadienamide, 7-(2'-(1,6-dimethyl-2,4-heptadienyl)(2,4'-bithiazol)-4-yl)-3,5-dimethoxy-4-methyl-

物理化学性质

沸点679.6±65.0 °C(Predicted)
密度1.158±0.06 g/cm3(Predicted)
储存条件-20°C
溶解度氯仿:可溶9.80 - 10.20mg/mL,透明,无色至黄色
酸度系数(pKa)14.07±0.50(Predicted)
形态Solid
颜色White to off-white

安全数据

危险性符号(GHS)
GHS06
警示词危险
危险性描述H300
危险品标志T+
危险类别码28
安全说明28-36/37-45
危险品运输编号UN 3462 6.1/PG 1
WGK Germany3
RTECS号QH7580000
危险等级6.1(b)
包装类别III
粘噻唑价格(试剂级)
报价日期产品编号产品名称CAS号包装价格
2024/04/30HY-112177粘噻唑
Myxothiazol
76706-55-31 mg4200元
2023/03/20HY-112177粘噻唑
Myxothiazol
76706-55-35 mg10500元

常见问题列表

生物活性
Myxothiazol 是一种抗真菌抗生素,是线粒体电子传递链复合体 Ⅲ (complex III or bc1 complex) 抑制剂。Myxothiazol 在0.01~3 μg/ml 浓度范围内可抑制许多酵母菌和真菌的生长。
体外研究

Myxothiazol inhibits the growth of many yeasts and fungi at concentrations between 0.01 and 3 μg/ml.
Myxothiazol binds to the ubiquinol oxidation site Qo of complex III and blocks electron transfer from ubiquinol to cytochrome b and thus inhibits complex III activity.

体内研究

Myxothiazol (i.p.; 0.56 mg/kg; daily for 4 days)-induced complex III inhibition can be induced in mice for four days in a row without overt hepatotoxicity or lethality.

Animal Model: C57Bl/J6 mice
Dosage: 0.56 mg/kg
Administration: I.p.; 24 hours intervals for at most 4 times
Result: A reversible complex III activity decrease to 50% of control value occurred at 2 h post-injection. At 74 h only minor histological changes in the liver were found, supercomplex formation was preserved and no significant changes in the expression of genes indicating hepatotoxicity or inflammation were found.
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