76706-55-3
中文名称
粘噻唑
英文名称
MYXOTHIAZOL
CAS
76706-55-3
分子式
C25H33N3O3S2
分子量
487.68
MOL 文件
76706-55-3.mol
更新日期
2023/03/20 15:41:19
76706-55-3 结构式
基本信息
中文别名
粘噻唑 英文别名
MyxothiazoMYXOTHIAZOL
5-dimethoxy-4-methyl-
myxothiazolfrommyxobacterium
MYXOTHIAZOL, VIAL WITH 10 MG*
MYXOTHIAZOL FROM MYXOBACTERIUM 95%
MYXOTHIAZOL, FROM MYXOCOCCUS FULVUS
myxothiazol from myxobacterium*myxococcus fulvus
7-(2’-(1,6-dimethyl-2,4-heptadienyl)(2,4’-bithiazol)-4-yl)-6-heptadienamide
2,6-Heptadienamide, 7-(2'-(1,6-dimethyl-2,4-heptadienyl)(2,4'-bithiazol)-4-yl)-3,5-dimethoxy-4-methyl-
物理化学性质
沸点679.6±65.0 °C(Predicted)
密度1.158±0.06 g/cm3(Predicted)
储存条件-20°C
溶解度氯仿：可溶9.80 - 10.20mg/mL，透明，无色至黄色
酸度系数(pKa)14.07±0.50(Predicted)
形态Solid
颜色White to off-white
安全数据
警示词危险
危险性描述H300
危险品标志T+
危险类别码28
安全说明28-36/37-45
危险品运输编号UN 3462 6.1/PG 1
WGK Germany3
RTECS号QH7580000
F10
危险等级6.1(b)
包装类别III
粘噻唑价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/04/30 | HY-112177 | 粘噻唑 Myxothiazol | 76706-55-3 | 1 mg | 4200元 |
| 2023/03/20 | HY-112177 | 粘噻唑 Myxothiazol | 76706-55-3 | 5 mg | 10500元 |
常见问题列表
生物活性
Myxothiazol 是一种抗真菌抗生素，是线粒体电子传递链复合体 Ⅲ (complex III or bc1 complex) 抑制剂。Myxothiazol 在0.01~3 μg/ml 浓度范围内可抑制许多酵母菌和真菌的生长。体外研究
Myxothiazol inhibits the growth of many yeasts and fungi at concentrations between 0.01 and 3 μg/ml.
Myxothiazol binds to the ubiquinol oxidation site Qo of complex III and blocks electron transfer from ubiquinol to cytochrome b and thus inhibits complex III activity.
体内研究
Myxothiazol (i.p.; 0.56 mg/kg; daily for 4 days)-induced complex III inhibition can be induced in mice for four days in a row without overt hepatotoxicity or lethality.
| Animal Model: | C57Bl/J6 mice |
| Dosage: | 0.56 mg/kg |
| Administration: | I.p.; 24 hours intervals for at most 4 times |
| Result: | A reversible complex III activity decrease to 50% of control value occurred at 2 h post-injection. At 74 h only minor histological changes in the liver were found, supercomplex formation was preserved and no significant changes in the expression of genes indicating hepatotoxicity or inflammation were found. |