76956-02-0

中文名称拉伏替丁

英文名称 Lavoltidine

CAS 76956-02-0

分子式 C19H29N5O2

分子量 359.47

MOL 文件 76956-02-0.mol

76956-02-0 结构式

基本信息常见问题列表

基本信息

中文别名

拉伏替丁

英文别名

Loxtidina
loxtidine
AH-234844
Lavoltidine
Lavoltidina
Lavoltidinum
Lavoltidine [inn:ban]
Lavoltidinum [inn-latin]
Lavoltidina [inn-spanish]
86160-82-9 (Hemisuccinate[1:1])

常见问题列表

生物活性

Lavoltidine (Loxtidine) 是一种具有口服活性的，不可逆且高效的组胺 H2 受体拮抗剂。Lavoltidine 强烈抑制胃酸分泌，并诱发高胃泌素血症。

靶点

H ₂ Receptor

体内研究

Lavoltidine (Loxtidine; 0.5 g/L; orally (drinking water); changed weekly; for 3 months) shows partial suppression of both gastric acid secretion and progression to neoplasia. Lavoltidine inhibits gastric atrophy, hyperplasia, and dysplasia in H felis -infected INS-GAS mice.
Lavoltidine treatment for 6 months inhibits gastric tumors in H felis -infected INS-GAS mice.

Animal Model:	Male hypergastrinemic mice (INS-GAS mice) infected with Helicobacter felis
Dosage:	0.5 g/L
Administration:	Orally (drinking water); changed weekly; for 3 months
Result:	Showed partial suppression of both gastric acid secretion and progression to neoplasia.