7761-45-7
中文名称
氯苯氨啶
英文名称
Metoprine
CAS
7761-45-7
分子式
C11H10Cl2N4
分子量
269.13
MOL 文件
7761-45-7.mol
更新日期
2023/03/20 15:41:23
![7761-45-7 结构式](/CAS/GIF/7761-45-7.gif)
基本信息
中文别名
氯苯氨啶5-(3,4-二氯苯基)-6-甲基嘧啶-2,4-二胺
英文别名
DDMPU-197
BW 197U
SK 5265
NSC 7364
NSC-19494
BW-50-197
Metoprine
methodichlorophen
2,4-DIAMINO-5-(3,4-DICHLOROPHENYL)-6-METHYLPYRIMIDINE
物理化学性质
熔点275-276℃
沸点418.42°C (rough estimate)
密度1.447
折射率1.6300 (estimate)
储存条件Hygroscopic, Refrigerator, under inert atmosphere
溶解度DMSO(略微加热)、甲醇(略微加热、超声处理)
形态固体
颜色灰白色至淡黄色
稳定性吸湿性
常见问题列表
生物活性
Metoprine (BW 197U) 是一种有效的组胺 N-甲基转移酶 (HMT) 抑制剂。Metoprine 是一种二氨基嘧啶衍生物,可以透过血脑屏障,并通过抑制 HMT 增加脑组胺水平。Metoprine 是一种抗叶酸 (antifolate) 和抗肿瘤药。体内研究
Metoprine (BW 197U; 2-10 mg/kg; IP) ameliorates the memory deficits induced by nucleus basalis magnocellularis (NBM) lesions in a dose-dependent manner.
Intraperitoneal administration of Metoprine produces various behavioral effects, including decreases in food intake and increases in water consumption.
Animal Model: | Male Sprague-dawley rats (200-280g) |
Dosage: | 2, 5, 10 mg/kg |
Administration: | IP |
Result: | Ameliorated the memory deficits induced by nucleus basalis magnocellularis (NBM) lesions in a dose-dependent manner and significanty prolonged transfer latency at a high dose of 10 mg/kg. |