785804-17-3
中文名称
Abarelix (acetate)
英文名称
Abarelix (acetate)
CAS
785804-17-3
分子式
C74H99ClN14O16
分子量
1476.14
MOL 文件
785804-17-3.mol
785804-17-3 结构式
应用领域
用途一
Abarelix acetate is a synthetic third generation gonadotropin-releasing hormone receptor (GnRHR) antagonist. It increases histamine release from rat peritoneal mast cells in vitro and from a human skin model ex vivo. In vivo, abarelix decreases plasma luteinizing hormone (LH) levels six hours post-treatment in castrated rats, with levels returning to baseline within 24 hours.3 Abarelix (2 mg/kg) also transiently decreases plasma testosterone levels in intact rats, with levels returning to baseline within seven days post-treatment. Formulations containing abarelix have previously been used in the treatment of advanced prostate cancer.