79756-69-7
79756-69-7 结构式
基本信息
TPI1
TPI 1
2-(2,5-Dichlorophenyl)-1,4-benzoquinone
Recombinant Human TIM/TPI1 Protein, His Tag
2,5-Cyclohexadiene-1,4-dione, 2-(2,5-dichlorophenyl)-
物理化学性质
常见问题列表
| Target | Value |
|
SHP-1
(Cell-free assay) | 40 nM |
SHP-1 has been implicated as a potential cancer therapeutic target. TPI-1 is effective starting at 10 ng/mL in increasing SHP-1 phospho-substrates pLck-pY394. TPI-1 selectively increases SHP-1 phospho-substrates (pLck-pY394, pZap70 and pSlp76) in Jurkat T cells but has little effects on pERK1/2 or pLck-pY505. TPI-1 induces mouse splenic-IFNγ + cells and induces IFNγ + cells in human peripheral blood.
TPI-1 inhibits the growth of B16 melanoma tumors in mice at a tolerated oral dose in a T cell-dependent manner but has little effects on B16 cell growth in culture. TPI-1 thus also increases pLck-pY394 and IFNγ + cells in mice. TPI-1 also inhibits B16 tumor growth and prolongs tumor mice survival as a tolerated s.c. agent.