80937-31-1

中文名称氟舒胺

英文名称 Flosulide

CAS 80937-31-1

分子式 C16H13F2NO4S

分子量 353.34

MOL 文件 80937-31-1.mol

80937-31-1 结构式

基本信息物理化学性质安全数据常见问题列表

基本信息

中文别名

氟舒胺

英文别名

ZK-38997
CGP-28328
CGP-28238
Flosulide
N-[1-Oxo-6-(2,4-difluorophenoxy)indan-5-yl]methanesulfonamide
N-[[6-(2,4-Difluorophenoxy)-2,3-dihydro-1-oxo-1H-inden]-5-yl]methanesulfonamide
Methanesulfonamide, N-[6-(2,4-difluorophenoxy)-2,3-dihydro-1-oxo-1H-inden-5-yl]-

物理化学性质

熔点156 °C(Solv: ethanol (64-17-5))

沸点446.9±55.0 °C(Predicted)

密度1.506±0.06 g/cm3(Predicted)

储存条件-20°C储存

溶解度溶于二甲基亚砜

酸度系数(pKa)6.95±0.20(Predicted)

安全数据

危险性符号(GHS)

GHS07

警示词警告

危险性描述H302-H315-H319-H335

防范说明P261-P305+P351+P338

常见问题列表

生物活性

Flosulide 是一种有效的，选择性的 COX-2 抑制剂，常用于炎症研究。

靶点

COX-2

体外研究

Flosulide (1 nM-100 μM) causes a concentration-dependent and finally complete inhibition of PGE2 production in the OSC-2 cell line, but with no effect on PG formation in the OSC-1 cells. Flosulide completely suppresses mitotic activity of OSC-2 cells, whereas mitotic activity of OSC-1 cells remain unchanged.

体内研究

In normovolemic rats, flosulide increases renal plasma flow (RPF) and and glomerular filtration rate (GFR). In hypovolemic rats, flosulide (5-25 mg/kg) reduces RPF and GFR. Flosulide at 5 mg/kg reduces 6-keto-PGF1alpha whereas at 25 mg/kg and after indomethacin at 10 mg/kg a fall in 6-keto-PGF1alpha and TXB2 appeares. Flosulide (0.75 mg/day) significantly reduces proteinuria as compared to aspirin treatment. Plasma protein and albumin levels are significantly lower in the aspirin-treated group than in flosulide-treated rats.