81424-67-1
81424-67-1 结构式
基本信息
中文别名
卡醋胺 英文别名
CaracemideNSC-253272
N-Acetyl-N-(methylcarbamoyloxy)-N'-methylurea
N-(Methylcarbamoyl)-N-((methylcarbamoyl)oxy)acetamide
物理化学性质
熔点122.25°C
沸点324.41°C (rough estimate)
密度1.4204 (rough estimate)
折射率1.5500 (estimate)
储存条件-20°C储存
溶解度溶于二甲基亚砜
酸度系数(pKa)11.18±0.46(Predicted)
形态Solid
颜色White to off-white
常见问题列表
生物活性
Caracemide (NSC-253272) 可以抑制大肠杆菌的核糖核苷酸还原酶。Caracemide是衍生自异羟肟酸的新型抗癌药,会产生严重的中枢神经系统 (CNS) 毒性。体外研究
Caracemide inactivates R1 by covalent modification at the substrate-binding site and has a toxic metabolite, methylisocyanate (MIC), in vivo.
体内研究
The mercapturic acid derivative AMCC was identified in urine rats following administration to rats of a single i.p. dose (6.6 mg/kg) of caracemide (NSC-253272).
.