828288-98-8
828288-98-8 结构式
物理化学性质
密度2.14±0.1 g/cm3(Predicted)
储存条件-20°C储存
溶解度DMSO : ≥ 100 mg/mL (216.73 mM)
酸度系数(pKa)0.90±0.70(Predicted)
形态Solid
颜色White to off-white
常见问题列表
生物活性
Asp-AMS是天冬氨酸腺苷酸的一个类似物，是 aspartyl-tRNA 合成酶 (aspartyl-tRNA synthetase) 的一个抑制剂，也是线粒体酶 (mitochondrial enzyme) 的强效竞争性抑制剂。靶点
Aspartyl-tRNA synthetase, Mitochondrial enzyme .
体外研究
Asp-AMS is a 500-fold stronger competitive inhibitor of the mitochondrial enzyme than aspartol-AMP (10 nM) and a 35-fold lower competitor of human and bovine cyt-AspRSs (300 nM). Asp-AMS is a strong inhibitor with K i in the nanomolar (nM) range. Asp-AMS has also the highest inhibitory effect for the mitochondrial enzyme. Asp-AMS is the most active inhibitor with K i values in the nanomolar range, with a stronger effect on bacterial AspRSs ( E. coli and P. aeruginosa ) than on human cytosolic AspRS.