842148-40-7
中文名称
AKT 激酶抑制剂
英文名称
AKT Kinase Inhibitor
CAS
842148-40-7
分子式
C16H19N7O3
分子量
357.37
MOL 文件
842148-40-7.mol
842148-40-7 结构式
基本信息
中文别名
AKT 激酶抑制剂AKT抑制剂(AKT KINASE INHIBITOR)
英文别名
3-[2-(4-amino-15-c]pyridin-4-yl]-
AKT Kinase Inhibitor
AKT Kinase Inhibitor USP/EP/BP
5-oxadiazol-3-yl)-7-(3-aminopropoxy)-1-ethyl-1H-imidazo[4
3-[2-(4-Amino-1,2,5-oxadiazol-3-yl)-7-(3-aminopropoxy)-1-ethyl-1H-imidazo[4,5-c]pyridin-4-yl]-2-propyn-1-ol
2-Propyn-1-ol, 3-[2-(4-aMino-1,2,5-oxadiazol-3-yl)-7-(3-aMinopropoxy)-1-ethyl-1H-iMidazo[4,5-c]pyridin-4-yl]-
AKT Kinase Inhibitor (2-Propyn-1-ol, 3-[2-(4-amino-1,2,5-oxadiazol-3-yl)-7-(3-aminopropoxy)-1-ethyl-1H-imidazo[4,5-c]pyridin-4-yl]-)
所属类别
生物化工：Akt 抑制剂物理化学性质
沸点678.8±65.0 °C(Predicted)
密度1.50
储存条件-20°C储存
溶解度DMSO : 16.67 mg/mL (46.65 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
酸度系数(pKa)12.98±0.10(Predicted)
形态粉末
颜色White to light yellow
常见问题列表
生物活性
AKT Kinase Inhibitor 是一种具有抗肿瘤活性的 Akt 抑制剂。靶点
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Akt
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体外研究
The effect of selective inhibition of Akt in proliferating cells expressing Trop-2 is studied. Akt inhibition, either by silencing or with specific drugs, induces a marked decrease in cell proliferation in cells expressing Trop-2, in a dose-dependent fashion.
体内研究
Trop-2 expressing tumors subcutaneously injected in animal models show a striking reduction of growth following treatment with specific drugs that inhibit Akt activity. Therefore Akt has a central functional role in mediating the Trop-2-dependent growth stimulus.