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847829-41-8

中文名称 Tat-NR2Baa
英文名称 Tat-NR2Baa
CAS 847829-41-8
分子式 C103H184N42O29
分子量 2474.87
MOL 文件 847829-41-8.mol
847829-41-8 结构式 847829-41-8 结构式

基本信息

中文别名
H-TYR-GLY-ARG-LYS-LYS-ARG-ARG-GLN-ARG-ARG-ARG-LYS-LEU-SER-SER-ILE-GLU-ALA-ASP-ALA-OH
英文别名
Tat-NR2Baa
L-Alanine, L-tyrosylglycyl-L-arginyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-glutaminyl-L-arginyl-L-arginyl-L-arginyl-L-lysyl-L-leucyl-L-seryl-L-seryl-L-isoleucyl-L-α-glutamyl-L-alanyl-L-α-aspartyl-

物理化学性质

密度1.52±0.1 g/cm3(Predicted)
储存条件-20°C储存
形态Solid
颜色White to off-white
Tat-NR2Baa价格(试剂级)
报价日期产品编号产品名称CAS号包装价格
2024/04/30HY-P2307Tat-NR2Baa
Tat-NR2Baa
847829-41-81mg2200元
2024/04/30HY-P2307Tat-NR2Baa
Tat-NR2Baa
847829-41-85mg5500元
2024/04/30HY-P2307Tat-NR2Baa
Tat-NR2Baa
847829-41-810mg9500元

常见问题列表

生物活性
Tat-NR2BAA 是 Tat-NR2B9c (HY-P0117) 的对照肽 (control peptide),没有活性。Tat-NR2BAA 的序列与 Tat-NR2B9c 相似,但在 COOH 末端 tSXV 基序中有一个双点突变,这使得它无法结合 PSD-95。Tat-NR2B9c 是一种可通透细胞膜的多肽,破坏 PSD-95/NMDAR 的结合。
体外研究

Tat-NR2BAA (125 ng; 20 mins) does not effects interactions between PSD-95 and NR2B subunits. In contrast, coimmunoprecipitation of PSD-95 with NR2B subunits is markedly decreased in rats pretreated with the disrupting peptide Tat-NR2B9c in lumbar dorsal horn tissue. Tat-NR2Baa (125 ng or 1.25 μg; 20 minutes before collection of lumbar dorsal horn tissue) is the control group of Tat-NR2B9c. Tat-NR2B9c produces a significant and robust reduction of postdischarge, indicating the hyperexcitability of the cell. But Tat-NR2Baa has no effects, even at a dose 100× greater than the active peptide Tat-NR2B9c (HY-P0117).Tat-NR2Baa (1 μM; pre-treatment 1 hour) is the control group in the Co-IP assay. Tat-NR2B9c (1 μM) disrupts NR2B/PSD95 interaction, and the coupling of NR2B to PSD-95 is more sensitive than NR2A/PSD95 to disruption in hippocampal neurons.

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