848354-66-5

中文名称 NCH-51

英文名称 PTACH

CAS 848354-66-5

分子式 C20H26N2O2S2

分子量 390.56

MOL 文件 848354-66-5.mol

更新日期 2024/10/13 20:50:17

848354-66-5 结构式

基本信息物理化学性质安全数据图谱信息常见问题列表

基本信息

中文别名

化合物PTACH

英文别名

NCH 51
NCH51, >98%
PTACH?, >98%
PTACH (NCH-51)
HDAC Inhibitor XXII, NCH51
HDAC Inhibitor XXII, NCH51 - CAS 848354-66-5 - Calbiochem
Cpd 51, S-[6-(4-Phenyl-2-thiazolylcarbamoyl)hexyl] thioisobutyrate
S-(7-Oxo-7-((4-phenylthiazol-2-yl)amino)-heptyl) 2-methylpropanethioate
2-MethylpropanethioicacidS-[7-oxo-7-[(4-phenyl-2-thiazolyl)amino]heptyl]ester
Propanethioic acid,2-methyl-, S-[7-oxo-7-[(4-phenyl-2-thiazolyl)amino]heptyl] ester

所属类别

生物化工：激动剂抑制剂

物理化学性质

熔点127-128 °C(Solv: hexane (110-54-3); ethyl acetate (141-78-6))

密度1.181±0.06 g/cm3(Predicted)

储存条件2-8°C

溶解度在DMSO中的溶解度为26mg/mL

酸度系数(pKa)9.52±0.50(Predicted)

形态白色粉末

颜色White to off-white

安全数据

危险性符号(GHS)

GHS05

警示词危险

危险性描述H318-H413

防范说明P280-P305+P351+P338

危险品标志Xi

危险类别码41

安全说明26-39

WGK Germany3

图谱信息

NCH-51(848354-66-5)质谱(MS)
NCH-51(848354-66-5)核磁图(¹HNMR)

常见问题列表

生物活性

PTACH (NCH-51) 是一种有效的 HDAC 抑制剂，对 HDAC1，HDAC4 和 HDAC6 的 IC50 分别为 48 nM，32 nM 和 41 nM。PTACH 对多种癌细胞具有强大的生长抑制作用 (EC50 为 1.1-9.1 µM)。

靶点

HDAC1

48 nM (IC ₅₀ )

HDAC4

32 nM (IC ₅₀ )

HDAC6

41 nM (IC ₅₀ )

HIV-1

体外研究

PTACH (compound 51) treatment elevates the levels of acetylated histone H4 and p21 ^WAF1/CIP1 in a dose-dependent manner.
In cancer cell growth inhibition assay, PTACH (compound 51) shows strong activity. PTACH inhibits various cancer cells with EC50 values of 2.3 μM, 9.1 μM, 3.0 μM, 2.6 μM, 1.1 μM, 4.5 μM, 2.4 μM, 5.0 μM, and 4.5 μM for MDA-MB-231, SNB-78, HCT116, NCI-H226, LOX-IMVI, SK-OV-3, RXF-631L, St-4, and DU-145 cells, respectively.
PTACH (NCH-51) augments the HIV-1 production in latently infected OM10.1 cells and such reactivation is associated with a loss of HDAC1 occupancy and subsequent hyperacetylation of histones in nuc-1 at the HIV-1 promoter.

Western Blot Analysis

Cell Line:	HCT 116 cells
Concentration:	1 μM, 5 μM, 25 μM
Incubation Time:	8 hours
Result:	Gave rise to elevated and dose-dependent levels of acetylated histone H4 and p21 ^WAF1/CIP1 .