851536-75-9
基本信息
UMiroliMus
BIOLIMUS A9
BioliMus A9 UMiroliMus
BioliMus, BioliMus A9, TRM 986
Rapamycin, 42-O-(2-ethoxyethyl)-
物理化学性质
常见问题列表
Umirolimus is a macrocyclic triene lactone, developed with pharmacological properties specifically tailored for localized drug delivery. Umirolimus can be used drug-eluting stent (DES) applications. Owing to its enhanced lipophilicity,it is strongly attracted to binding sites within the vessel wall and small, tortuous vessels, and contributing to cellular absorption and sustained distribution in the vessel wall surrounding the stent.
Umirolimus prevents progression of the cell cycle in G1 phase by inhibiting IL-2/mTOR-mediated P70-KD S6 protein kinase activation. Umirolimus inhibits T-cell growth, as well as smooth muscle cell growth.
The elimination half-life of Umirolimus is approximately 25 h in whole blood.