853136-76-2

中文名称化合物 T27187

英文名称 4-Oxazolecarboxamide, 2-[[[3,4,5,6,7,8-hexahydro-4-oxo-3-(phenylmethyl)[1]benzothieno[2,3-d]pyrimidin-2-yl]thio]methyl]-N-[2-(1-pyrrolidinyl)ethyl]-

CAS 853136-76-2

分子式 C28H31N5O3S2

分子量 549.71

MOL 文件 853136-76-2.mol

853136-76-2 结构式

基本信息应用领域

基本信息

中文别名

化合物 T27187

英文别名

DK149
DK-1-49
DK 1 49
4-Oxazolecarboxamide, 2-[[[3,4,5,6,7,8-hexahydro-4-oxo-3-(phenylmethyl)[1]benzothieno[2,3-d]pyrimidin-2-yl]thio]methyl]-N-[2-(1-pyrrolidinyl)ethyl]-

应用领域

用途一

DK-1-49 is an autophagonizer. DK-1-49 causes accumulation of autophagy-associated LC3-II and enhanced levels of autophagosomes and acidic vacuoles. Furthermore, cell viability is inhibited by autophagic cell death in not only human cancer cells but also Bax/Bak double-knockout cells.