856307-27-2
856307-27-2 结构式
基本信息
安乃近杂质C(EP)
4-甲氨基安替比林盐酸盐
安乃近杂质C(EP) 标准品
N-甲基-4-氨基安替比林盐酸盐
4-METHYLAMINOANTIPYRINE HYDROCHLORIDE
Metamizole EP Impurity C HCl
4-Methylamino-1,5-dimethyl-2-phenyl
4-Methylaminoantipyrine hydrochloride
N-Methyl-4-aminoantipyrine Hydrochloride
Antipyrine,4-(methylamino)-, hydrochloride
MetaMizole IMpurity C (4-MethylaMinoantipyrine) HCl
1,5-dimethyl-4-(methylamino)-2-phenylpyrazol-3-one:hydrochloride
3H-Pyrazol-3-one, 1,2-dihydro-1,5-dimethyl-4-(methylamino)-2-phenyl-, hydrochloride
物理化学性质
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/04/30 | HY-135731A | 安乃近杂质C 4-Methylamino antipyrine hydrochloride | 856307-27-2 | 100mg | 2450元 |
| 2024/01/25 | HY-135731A | 安乃近杂质C 4-Methylamino antipyrine hydrochloride | 856307-27-2 | 25mg | 1050元 |
| 2024/01/25 | HY-135731A | 安乃近杂质C 4-Methylamino antipyrine hydrochloride | 856307-27-2 | 50mg | 1550元 |
常见问题列表
COX
Metamizole is a prodrug which, at room temperature and in an atmosphere with oxygen, is spontaneously, nonenzymatically converted to 4-Methylamino antipyrine. Subsequently, the N-methyl side chain of 4-Methylamino antipyrine is oxidized to yield 4-formylaminoantipyrine, which is further converted to 4-aminoantipyrine. Metamizole in aqueous solution and in the presence of oxygen consists of a group of several pyrazolone derivatives of which 4-Methylamino antipyrine is pharmacologically the most important.
The aim of this study is to assess the pharmacokinetics of its active metabolites 4-Methylamino antipyrine in male piglets after a single intramuscular injection of Metamizole. Eight healthy male piglets are administered Metamizole (100 mg/kg) intramuscularly. 4-Methylamino antipyrine plasma concentrations are quantitatively detectable from 0.25 to 48 h. The average maximum concentration of 4-Methylamino antipyrine is of 47.59 mg/mL. The average half-lives is 8.57 h for 4-Methylamino antipyrine.