861214-33-7
中文名称
5'-Fluoro-1H,1'H-[2,3']biindolylidene-3,2'dione3-oxime
英文名称
5'-Fluoro-1H,1'H-[2,3']biindolylidene-3,2'dione3-oxime
CAS
861214-33-7
分子式
C16H10FN3O2
分子量
295.27
MOL 文件
861214-33-7.mol
更新日期
2023/03/20 15:41:21
![861214-33-7 结构式](/CAS/GIF/861214-33-7.gif)
基本信息
中文别名
化合物5'-FLUOROINDIRUBINOXIME5'-氟-3-(肟基)-[2,3'-双吲哚亚基]-2'-酮
英文别名
5'-FIO-Fluoroindirubinoxime
5'-Fluoroindirubinoxime
5'-Fluoro-1H,1'H-[2,3']biindolylidene-3,2'dione3-oxime
2H-Indol-2-one, 3-[1,3-dihydro-3-(hydroxyimino)-2H-indol-2-ylidene]-5-fluoro-1,3-dihydro-
物理化学性质
储存条件Keep in dark place,Sealed in dry,Store in freezer, under -20°C
溶解度DMSO : 83.33 mg/mL (282.22 mM; Need ultrasonic)
形态粉末
常见问题列表
生物活性
5'-Fluoroindirubinoxime (compound 13) 是Indirubin (HY-N0117) 的衍生物,是FLT3 的抑制剂,其IC50 值为15 nM。靶点
15 nM (FLT3).
体外研究
5'-Fluoroindirubinoxime (5’-FIO, compound 13) exhibits IC
50
values of 1.53 μM and 1.27 μM for VEGFR2 and Aurora A, respectively.
5'-Fluoroindirubinoxime (5’-FIO) exhibits IC
50
values of 12.2 μM, 2.1 μM, 3.4 μM and 5.1 μM in A549, SNU-638, HT-1080 and RK3E-ras cancer cells, respectively. 5'-Fluoroindirubinoxime (5’-FIO) induces the apoptosis in RK3E-ras cells.
体内研究
5'-Fluoroindirubinoxime (5’-FIO, 10 μmol/L/100 μL (~2.95 mg/mL) every other day beginning on day 6, S.C..) exhibits significant anti-tumor activity in rats.
Animal Model: | Rat tumor model based RK3E-ras cells. |
Dosage: | S.C.. |
Administration: | 10 μmol/L/100 μL (~2.95 mg/mL) every other day beginning on day 6. |
Result: | Effectively inhibited tumor growth. |