86408-36-8
中文名称
多粘菌素B九肽
英文名称
POLYMYXIN B NONAPEPTIDE HYDROCHLORIDE
CAS
86408-36-8
分子式
C43H74N14O11
分子量
963.13
MOL 文件
86408-36-8.mol
更新日期
2024/10/12 17:21:57
86408-36-8 结构式
基本信息
中文别名
多粘菌素B九肽多粘菌素B盐酸盐
阿维巴坦杂质66
英文别名
PMBNsPMBN
2-10-Polymyxin B1
polymyxinbnonapeptide
POLYMYXIN B NONAPEPTIDE HYDROCHLORIDE
N2-(L-Thr-L-A2bu-)Cyclo(L-A2bu*-L-A2bu-D-Phe-L-Leu-L-A2bu-L-A2bu-Thr-)
Nα-(L-Thr-L-A2bu-)Cyclo(L-A2bu*-L-A2bu-D-Phe-L-Leu-L-A2bu-L-A2bu-L-Thr-)
N2-(L-Thr-L-A2bu-)Cyclo(L-A2bu*-L-A2bu-D-Phe-L-Leu-L-A2bu-L-A2bu-L-Thr-)
所属类别
生物化工:多肽物理化学性质
储存条件2-8°C
溶解度Water: ≥ 100 mg/mL (103.83 mM); DMSO: 16.67 mg/mL (17.31 mM)
形态Solid
颜色White to off-white
序列H-Thr-Dab-Dab-Dab-d-Phe-Leu-Dab-Dab-Thr-OH(Lactam: Dab3-Thr10)
常见问题列表
生物活性
Polymyxin B nonapeptide 是一种阳离子环肽。Polymyxin B nonapeptide 是经酶裂解 Polymyxin B 而产生的衍生物,与 Polymyxin B 相比,Polymyxin B nonapeptide 毒性低,缺乏杀菌活性,仍具有破坏革兰氏阴性菌外膜的能力。体外研究
Polymyxin B nonapeptide, a cationic cyclic peptide derived by enzymatic processing from the naturally occurring peptide polymyxin B, is able to increase the permeability of the outer membrane of Gram-negative bacteria toward hydrophobic antibiotics probably by binding to the bacterial lipopolysaccharide (LPS).