872993-05-0
中文名称
(4Z,7S,8S,9E,11E,13Z,15E,17S,19Z)-7,8,17-TRIHYDROXYDOCOSA-4,9,11,13,15,19-HEXAENOIC ACID
英文名称
(4Z,7S,9E,11E,13Z,15E,17S,19Z)-7,8,17-trihydroxydocosa-4,9,11,13,15,19-hexaenoic acid
CAS
872993-05-0
分子式
C22H32O5
分子量
376.49
MOL 文件
872993-05-0.mol
872993-05-0 结构式
基本信息
中文别名
消退素D1(4Z,7S,8R,9E,11E,13Z,15E,17S,19Z)-7,8,17-三羟基-4,9,11,13,15,19-二十二碳六烯酸
英文别名
RVD1Resolvin D1
resolvin D1, CID73755062
Resolvin D1 Exclusive
OIWTWACQMDFHJG-CCFUIAGSSA-N
Resolvin D1 MaxSpec? Standard
(4Z,7S,9E,11E,13Z,15E,17S,19Z)-7,8,17-trihydroxydocosa-4,9,11,13,15,19-hexaenoic acid
(4Z,7S,8S,9E,11E,13Z,15E,17S,19Z)-7,8,17-TRIHYDROXYDOCOSA-4,9,11,13,15,19-HEXAENOIC ACID
4,9,11,13,15,19-Docosahexaenoic acid, 7,8,17-trihydroxy-, (4Z,7S,8R,9E,11E,13Z,15E,17S,19Z)-
物理化学性质
储存条件Store at -80°C,protect from light
溶解度DMF: 50 mg/ml; Ethanol: 50 mg/ml; PBS (pH 7.2): 0.05 mg/ml
形态Liquid
颜色Colorless to light yellow
(4Z,7S,8S,9E,11E,13Z,15E,17S,19Z)-7,8,17-TRIHYDROXYDOCOSA-4,9,11,13,15,19-HEXAENOIC ACID价格(试剂级)
报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
2024/04/30 | HY-125527 | (4Z,7S,8S,9E,11E,13Z,15E,17S,19Z)-7,8,17-TRIHYDROXYDOCOSA-4,9,11,13,15,19-HEXAENOIC ACID Resolvin D1 | 872993-05-0 | 25μg(265.6μM * 250μL in Ethanol) | 8500元 |
常见问题列表
生物活性
Resolvin D1 (RvD1) 是炎症的一种内源性促分解介质,衍生自在急性炎症的缓解阶段的 omega-3二十二碳六烯酸。Resolvin D1 通过调节肌动蛋白聚合来阻止促炎性中性粒细胞迁移,减少巨噬细胞中 TNF-α 介导的炎症,并增强巨噬细胞对凋亡细胞的吞噬作用。靶点
Human Endogenous Metabolite
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体外研究
Resolvin D1 (RvD1) (1-100 nM; 15 minutes) induces dose-dependent short-term functional changes in primary human macrophages. RvD1 triggers intracellular Ca 2+ release, blocks chemotactic migration, and stimulates phagocytosis of microbial particles with maximal efficiency at 10 nM. Resolvin D1 (0-500 nM; 72 hours) shows a strong inhibition of LPS-induced TRAP and cathepsin K expression by RvD1 at different concentrations in RAW264.7 macrophages.
体内研究
Resolvin D1 (RvD1) (100-1000 ng; i.p.; daily on days 10) improves RA (rheumatoid arthritis) clinical endpoints in arthritic mice.
Animal Model: | 18-20 g thirty 8-week-old female DBA/1J mice (collagen antibody-induced arthritis (CAIA)) |
Dosage: | 100, 500, and 1000 ng (or 1000 ng, daily on days 4-10) |
Administration: | i.p. injection; daily on days 10 |
Result: | Exhibit a reduced arthritic score. |