87468-58-4
中文名称
BIOTIN-ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-NH2
英文名称
BIOTINYL-SUBSTANCE P
CAS
87468-58-4
分子式
C73H112N20O15S2
分子量
1573.93
MOL 文件
87468-58-4.mol
87468-58-4 结构式
基本信息
中文别名
BIOTIN-SUBSTANCE P,BIOTIN-RPKPQQFFGLM-NH2 英文别名
AbaspBIOTIN-SUBSTANCE P
BIOTINYL-SUBSTANCE P
BIOTIN-RPKPQQFFGLM-NH2
alpha-Biotinyl-1-Arg-substance p
substance P, alpha-biotinyl-Arg(1) -
Substance p, alpha-biotinyl-arginine(1)-
1H-Thieno[3,4-d]imidazole,substance P deriv.
BIOTIN-ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-NH2
BIOTINYL-ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-NH2
物理化学性质
储存条件-20°C储存
溶解度溶于二甲基亚砜
形态固体
颜色White to off-white
水溶解性Soluble in water at 2mg/ml; also soluble in acetonitrile
常见问题列表
生物活性
Biotin-Substance P (Neurokinin P) 是一种神经肽，在中枢神经系统中作为神经递质和神经调节剂。Substance P 的内源性受体是神经激肽1受体 (neurokinin 1 receptor，NK1R)体外研究
The neuropeptide substance P (SP) that are mediated by the neurokinin 1 receptor (NK1-R) desensitize and resensitize, which may be associated with NK1-R endocytosis and recycling. SP and the NK1-R are internalized into the same clathrin immunoreactive vesicles, and then sorted into different compartments. SP is intact at the cell surface and in early endosomes, but slowly degraded in perinuclear vesicles. SP induces clathrin-dependent internalization of the NK1-R. The SP/NK1-R complex dissociates in acidified endosomes. SP is degraded, whereas the NK1-R recycles to the cell surface. SP induces internalization of the NK1-R both in transfected epithelial cells.