88678-67-5
![88678-67-5 结构式](/CAS/GIF/88678-67-5.gif)
基本信息
椑草畏
稗草畏
稗草畏标准物质
稗草丹 标准品
稗草丹(稗草畏)
甲苯中稗草丹标准品
甲醇中稗草丹溶液,100ΜG/ML
O-3-特丁基苯基-6-甲氧基-2-吡啶(甲基)硫代氨基甲酸酯
O-3-特丁基苯基-6-甲氧基-2-(吡啶(甲基)硫代氨基甲酸酯
Seexet
tsh-888
Oryzaguard
henyl)ester
PYRIBUTYCARB
PYRIBUTICARB
Pyributicarb [iso]
Pyributicarb Reference Material
Pyributicarb@100 μg/mL in Methanol
物理化学性质
常见问题列表
稗草畏为白色结晶固体,熔点85.7~86.2℃,蒸气压0.0119mPa(40℃),相对密度1.20(20℃),水中溶解度0.15mg/L(20℃),有机溶剂中溶解度(20℃,g/L): 丙酮454,甲醇21,乙醇33,二甲苯355,乙酸乙酯384。273℃以下均稳定。
大、小鼠急性经口LD₅₀>5000mg/kg, 大鼠急性经皮 LD₅₀>5000mg/kg。对兔眼睛和皮肤无刺激性作用,对豚鼠皮肤无致敏性。大鼠急性吸入 LC₅₀(4h)>6.52mg/L。大鼠NOEL(2y)0.881mg/kg 。ADI 0.0088mg/kg。
稗草畏可用于:
(1)适宜作物水稻、草坪。
(2)防除对象 在水田条件下,对稗属、异型莎草和鸭舌草的活性高于多年生杂草活性。在旱田条件下,对稗草、马唐和狗尾草等禾本科杂草有较高活性。
本药剂在苗前至苗后早期施药,使用适期为苗前至2叶期,对移栽水稻安全。对一年生禾本科杂草有很高的除草活性,对稗草的防效更为优异。
CYP3A4, hPXR
Pyributicarb, a carbamate-type herbicide, is a potent activator of both CYP3A4 gene and human pregnane X receptor (hPXR). Pyributicarb is found to increase the CYP3A4 reporter activity at 0.1 to 1 μM more strongly than typical CYP3A4 inducer rifampicin. Expression of hPXR-siRNA clearly diminishes the Pyributicarb-stimulated CYP3A4 reporter activity in 3-1-10 cells and decreases the endogenous CYP3A4 mRNA levels in HepG2 cells. Pyributicarb induces luciferase transcription via hPXR at low concentrations in the order of 10 nM. The relative potency of Pyributicarb for hPXR is 8.6-fold that of rifampicin (RIF).
Pyributicarb causes enhancement of CYP3A4 -derived reporter activity in mouse livers introduced with hPXR by adenovirus.