89197-00-2
中文名称
依法克生
英文名称
EFAROXAN HYDROCHLORIDE
CAS
89197-00-2
分子式
C13H17ClN2O
分子量
252.74
MOL 文件
89197-00-2.mol
89197-00-2 结构式
基本信息
中文别名
盐酸盐依法克生PO20090827-EFAROXAN
英文别名
RX 821037AEfaroxanHCl
Zinc00002748
PO20090827-Efaroxan
EFAROXAN HYDROCHLORIDE
2-ETHYL-2-(IMIDAZOLIN-2-YL)-2,3-DIHYDROBENZOFURAN HYDROCHLORIDE
2-(2-ETHYL-2,3-DIHYDROBENZOFURAN-2-YL)-4,5-DIHYDRO-1H-IMIDAZOLE HCL
2-(2-ETHYL-2,3-DIHYDRO-2-BENZOFURANYL)-4,5-DIHYDRO-1H-IMIDAZOLE HYDROCHLORIDE
2-(2-Ethyl-2,3-dihydrobenzofuran-2-yl)-4,5-dihydro-1H-imidazole hydrochloride
RX 821037A, 2-Ethyl-2-(imidazolin-2-yl)-2,3-dihydrobenzofuran hydrochloride
所属类别
生物:拮抗剂常见问题列表
生物活性
Efaroxan hydrochloride 是一种有效的,选择性的,具有口服活性的 α2 肾上腺素受体 (α2-adrenoceptor) 拮抗剂,具有抗糖尿病的活性。Efaroxan hydrochloride 是一种选择性的 I1 咪唑啉受体 (I1-Imidazoline receptor) 拮抗剂,可用于心血管疾病的研究。靶点
α2-adrenoceptor, I1-Imidazoline receptor
体外研究
Efaroxan hydrochloride binds to I1-imidazoline and α2-adrenergic receptors in bovine rostral ventrolateral medulla membranes, with K i s of 0.15 nM and 5.6 nM, respectively
体内研究
Efaroxan hydrochloride increases plasma insulin levels in both conscious fed and fasted rats without greatly affecting plasma glucoselevels.
Animal Model: | Male Sprague-Dawley rats (weight range 250-300g) |
Dosage: | 1 mg/kg, 5 mg/kg |
Administration: | Oral administration |
Result: | Produced a significant increase in plasma insulin levels of starved rats 15 and 30 min after treatment. |