89396-94-1
中文名称
盐酸咪达普利
英文名称
(S)-3-[(S)-2-((S)-1-ETHOXYCARBONYL-3-PHENYL-PROPYLAMINO)-PROPIONYL]-1-METHYL-2-OXO-IMIDAZOLIDINE-4-CARBOXYLIC ACID
CAS
89396-94-1
分子式
C20H27N3O6
分子量
405.445
MOL 文件
89396-94-1.mol
更新日期
2024/11/18 09:13:49
89396-94-1 结构式
基本信息
中文别名
咪达普利盐酸盐咪达普利及其中间体
(S)-3-((S)-2-(((S)-1-乙氧基-1-氧代-4-苯基丁烷-2-基)氨基)丙酰基)-1-甲基-2-氧代咪唑啉-4-羧酸盐酸盐
英文别名
TA 6366Novaloc
SH-6366
Novarok
Tanapril
Tanatril
ACE/TA-6366
IMipadril HCl
Imidaprilhydrochloride
Imidapril HCl (TA-6366)
所属类别
原料药：抗高血压病药物理化学性质
熔点214-216℃
比旋光度D20 -64.1° (c = 0.5 in ethanol)
储存条件?20°C
溶解度H2O：≥5mg/mL
形态粉末
颜色白色至棕褐色
旋光性 (optical activity)[α]/D -50 to -70° in ethanol (c=0.5)
Merck14,4911
常见问题列表
生物活性
Imidapril HCl是一种血管紧张素转换酶（ACE）抑制剂，IC50为2.6 nM，用于治疗高血压。靶点
| Target | Value |
| ACE | 2.6 nM |
体外研究
As a prodrug, Imidapril is converted by hydrolysis in the liver into its active form imidaprilat. Imidaprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. Imidaprilat also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow.