90-18-6
基本信息
六羟黄酮/栎草亭
槲皮万寿菊素栎草亭
栎草亭,槲皮万寿菊素
3,3',4',5,6,7-六羟基黄酮
QUERCETAGETIN
QUERCETAGENIN
6-Hydroxyquercetin
6,7,4'-Quercetagetin
QUEBRACHITOL, (-)-(RG)
Quercetagetin 7-glucoside
3,5,6,7,3',4'-HEXAHYDROXYFLAVONE
3,3',4',5,6,7-HEXAHYDROXYFLAVONE
QuercetagitrinQuercetagetin 7-glucoside
物理化学性质
常见问题列表
PIM1 0.34 μM (IC 50 ) |
PIM2 3.45 μM (IC 50 ) |
RSK2 2.82 μM (IC 50 ) |
PKA 21.2 μM (IC 50 ) |
Quercetagetin also inhibits PIM2, PKA, and RSK2 with IC
50
s of 3.45, 21.2, and 2.82 µM, respectively.
Quercetagetin (0.1, 1, 10, and 100 μM, 72 hours) inhibits growth of RWPE2 prostate cancer cells with average ED
50
is 3.8 μM.
Cell Viability Assay
Cell Line: | RWPE2 prostate cancer cells |
Concentration: | 0.1, 1, 10, and 100 μM |
Incubation Time: | 72 hours |
Result: | Inhibited growth of RWPE2 prostate cancer cells with average ED 50 is 3.8 μM. |
Quercetagetin significantly inhibits UVB-induced skin cancer development. Topical application of 4 or 20 nmol of Quercetagetin to mouse skin reduces tumor incidence by 32.0% and 46.7%, respectively.
Animal Model: | SKH-1 hairless mice model |
Dosage: | 4 or 20 nmol |
Administration: | Topical application; 28 weeks |
Result: | Inhibited UVB-induced skin tumorigenesis in SKH-1 hairless mice models. Delayed the development of tumors and reduced tumor volumes in an SKH-1 hairless mice model. |