904680-01-9
英文名称
1-Naphthalenecarboxylic acid, 2-[[[2-[(1Z)-3-(dimethylamino)-1-propen-1-yl]-4-fluorophenyl]sulfonyl]amino]-5,6,7,8-tetrahydro-
CAS
904680-01-9
分子式
C22H25FN2O4S
分子量
432.51
MOL 文件
904680-01-9.mol
904680-01-9 结构式
基本信息
英文别名
1-Naphthalenecarboxylic acid, 2-[[[2-[(1Z)-3-(dimethylamino)-1-propen-1-yl]-4-fluorophenyl]sulfonyl]amino]-5,6,7,8-tetrahydro-应用领域
用途一
A-849519 is a reversible inhibitor of MetAP2 that has demonstrated anti-angiogenesis and anticancer activity in a number of in vitro and in vivo models. In this study, we evaluated the anticancer activity of A-849519 in a modified Dunning model of androgen-independent prostate cancer and compared its efficacy with TNP-470, an established MetAP2 inhibitor.