907952-06-1
中文名称
GPR34 RECEPTOR ANTAGONIST 2
英文名称
Tyrosine, N-[(2E)-3-(4'-chloro[1,1'-biphenyl]-4-yl)-1-oxo-2-propen-1-yl]-O-(phenylmethyl)-
CAS
907952-06-1
分子式
C31H26ClNO4
分子量
512
MOL 文件
907952-06-1.mol
更新日期
2024/07/23 09:41:47
907952-06-1 结构式
基本信息
中文别名
化合物T8848 英文别名
QQN52061GPR34 modulator 1
GPR34 receptor antagonist 2
Tyrosine, N-[(2E)-3-(4'-chloro[1,1'-biphenyl]-4-yl)-1-oxo-2-propen-1-yl]-O-(phenylmethyl)-
immune,inhibit,Inhibitor,GPR34,inflammatory,GPR34 receptor antagonist 2,GPR-34 receptor antagonist 2
物理化学性质
沸点763.7±60.0 °C(Predicted)
密度1.268±0.06 g/cm3(Predicted)
储存条件-20°C储存
溶解度DMSO: 83.33 mg/mL (162.75 mM)
酸度系数(pKa)3.06±0.10(Predicted)
形态Solid
颜色Off-white to gray
常见问题列表
生物活性
GPR34 receptor antagonist 2 (Compound D2) 是 GPR34 受体拮抗剂，可用于免疫疾病，炎性疾病的研究。靶点
GPR34 receptor
体外研究
Endogenous ligands of GPR34, a G protein-coupled receptor, act on histamine-releasing activity on antigen- or concanavalin A-stimulated rat mast cells and synergize with nerve growth factor on rat mast cells. It is a lipid such as lysophosphatidylserine having the activity of releasing histamine. GPR34 antagonists can be used, for example, for histamine release inhibitors, immune diseases, edema, hyperacidity, etc.