92092-36-9

中文名称 DIPHTHERIA TOXIN

CAS 92092-36-9

92092-36-9 结构式

基本信息物理化学性质安全数据常见问题列表

基本信息

英文别名

DIPHTHERIA TOXIN
Diphtheria toxin (CRM197)
DIPHTHERIA TOXIN, CRM MUTANT
CORYNEBACTERIUM DIPHTHERIAE TOXIN
(GLU-52)-DIPHTHERIA TOXIN FROM*CORYNEBAC
(glu52)-diphtheria toxin from*corynebacterium dip
Diphtheria Toxin from Corynebacterium diphtheriae
Diphtheria toxin[Glu-52], Corynebacterium diphtheriae
DIPHTHERIA TOXIN, UNNICKED, CORYNEBACTERIUM DIPHTHERIAE
[glu52]-diphtheria toxin from corynebacterium diphtheriae

物理化学性质

储存条件2-8°C

形态lyophilized powder

安全数据

危险性符号(GHS)

GHS06

警示词危险

危险性描述H300+H330

防范说明P301+P310+P330-P304+P340+P310

危险品标志T+

危险类别码28

安全说明22-24/25-45-36/37-28

危险品运输编号3172

WGK Germany3

RTECS号XW5807200

危险等级6.1(a)

包装类别I

常见问题列表

生物活性

Diphtheria toxin CRM197 是白喉毒素的一个无毒变种，具有一个单一的突变 (52 位的甘氨酸到谷氨酸的替代)，可以消除其毒性。CRM197 作为载体蛋白广泛应用于疫苗中。

体外研究

Diphtheria toxin CRM197 is an enzymatically inactive and nontoxic form of diphtheria toxin that contains a single amino acid substitution (G52E). Being naturally nontoxic, CRM197 is an ideal carrier protein for conjugate vaccines against encapsulated bacteria and is currently used to vaccinate children globally against Haemophilus influenzae, pneumococcus, and meningococcus.
Diphtheria toxin, a single polypeptide secreted by lysogenic strains of Corynebacterium diphtheria , causes the disease diphtheria in humans by gaining entry into the cytoplasm of cells and inhibiting protein synthesis.