92262-58-3
![92262-58-3 结构式](/CAS/GIF/92262-58-3.gif)
基本信息
N-丙戊酰基甘氨酰胺
N-(2-氨基-2-氧代乙基)-2-丙基戊酰胺
VALROCEMIDE
Valrocemide, >98%
N-Valproylglycinamide
Valrocemide (TV1901,VGD))
N-(2-Amino-2-oxoethyl)-2-propylpentanamide
物理化学性质
报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
2024/08/19 | HY-100379 | N-丙戊酰基甘氨酰胺 Valrocemide | 92262-58-3 | 5mg | 850元 |
2024/08/19 | HY-100379 | N-丙戊酰基甘氨酰胺 Valrocemide | 92262-58-3 | 10mM * 1mLin DMSO | 935元 |
2024/08/19 | HY-100379 | N-丙戊酰基甘氨酰胺 Valrocemide | 92262-58-3 | 10mg | 1250元 |
常见问题列表
In mice, valrocemide affords complete protection against maximal electroshock-, pentylenetetrazole-, picrotoxin-, and bicuculline-induced seizures and 6-Hz “psychomotor” seizures with median effective dose (ED 50 ) values of 151, 132, 275, 248, and 237 mg/kg, respectively. Valrocemide is also effective in preventing sound-induced seizures in Frings audiogenic-seizure susceptible mice (ED 50 , 52 mg/kg). The median neurotoxic dose in mice is 332 mg/kg. After oral administration to rats, valrocemide is active in the MES test, with an ED 50 of 73 mg/kg, and the median neurotoxic dose is 1,000 mg/kg. Intraperitoneal administration of 300 mg/kg of valrocemide to hippocampal kindled Sprague–Dawley rats block generalized seizures and shorten the afterdischarge duration significantly. Valrocemide also provides complete protection from focal seizures in the corneally kindled rats (ED 50 , 161 mg/kg).