924473-59-6

中文名称 T5601640

英文名称 T5601640

CAS 924473-59-6

分子式 C19H14F3N3O3

分子量 389.33

MOL 文件 924473-59-6.mol

更新日期 2023/03/20 15:41:27

924473-59-6 结构式

基本信息物理化学性质安全数据 T5601640价格(试剂级) 常见问题列表

基本信息

中文别名

化合物T56-LIMKI
LIMK2抑制剂(T56-LIMKI)

英文别名

T5601640
T56-LIMKi
T-5601640(T56-LIMKi)
T56-LIMKi - T5601640
T5601640
T 5601640
T56-LIMKI
3-methyl-N-[3-[[3-(trifluoromethyl)phenyl]carbamoyl]phenyl]-1,2-oxazole-5-carboxamide
3-Methyl-N-[3-[[[3-(trifluoromethyl)phenyl]amino]carbonyl]phenyl]-5-isoxazolecarboxamide
5-Isoxazolecarboxamide, 3-methyl-N-[3-[[[3-(trifluoromethyl)phenyl]amino]carbonyl]phenyl]-

所属类别

生物化工：激动剂抑制剂

物理化学性质

沸点403.4±45.0 °C(Predicted)

密度1.426±0.06 g/cm3(Predicted)

储存条件2-8°C

溶解度DMF: 30 mg/ml; DMF:PBS(pH7.2) (1:2): 0.33 mg/ml; DMSO: 20 mg/ml

酸度系数(pKa)11.41±0.70(Predicted)

形态粉末

颜色白色至米色

安全数据

危险性符号(GHS)

GHS06

警示词危险

危险性描述H301-H413

防范说明P273-P301+P310+P330

危险品运输编号UN 2811 6.1 / PGIII

T5601640价格(试剂级)

报价日期	产品编号	产品名称	CAS号	包装	价格
2024/08/19	HY-19352	T5601640 T56-LIMKi	924473-59-6	5mg	500元
2024/08/19	HY-19352	T5601640 T56-LIMKi	924473-59-6	10mM * 1mLin DMSO	550元
2024/08/19	HY-19352	T5601640 T56-LIMKi	924473-59-6	10mg	850元

常见问题列表

生物活性

T56-LIMKi是LIM kinase 2 (LIMK2)抑制剂，抑制LIMK2介导的丝切蛋白磷酸化。

靶点

Target	Value
LIMK2 ()

体外研究

T56-LIMKi efficiently inhibits the growth of ST88-14, U87, Panc-1 cells, A549 lung cancer cells with IC ₅₀ values of 18.3, 7.4, 35.2 and 90 μM, respectively. T56-LIMKi decreases phosphorylated cofilin (p-cofilin) levels and thus inhibits growth of several cancerous cell lines, including those of pancreatic cancer, glioma and schwannoma. It blocks the phosphorylation of cofilin which leads to actin severance and inhibition of tumor cell migration, tumor cell growth, and anchorage-independent colony formation in soft agar. T56-LIMKi (10-50 μM) reduces p-cofilin in a dose-dependent manner in NF1 ^−/− MEFs with an IC ₅₀ of 30 μM. Notably, the inhibitor does not affect the amounts of total cofil. 50μM T56-LIMKi causes a statistically significant reduction in the number of cells exhibiting stress fibers.

体内研究

T56-LIMKi can induce inhibition of cofilin phosphorylation and Panc-1 tumor shrinkage in vivo . Mice treated with T56-LIMKi (60 mg/kg) shows a significant decrease in tumor volume compared to control.