929895-45-4
中文名称
929895-45-4
英文名称
Phen-DC3 Trifluoromethanesulfonate
CAS
929895-45-4
分子式
C36H26F6N6O8S2
分子量
848.747
MOL 文件
929895-45-4.mol
929895-45-4 结构式
基本信息
中文别名
解旋酶FANCJ和DING抑制剂 英文别名
Phen-DC3 TriflatePhen-DC3 Trifluoromethanesulfonate
所属类别
有机原料：烃类化合物及其衍生物物理化学性质
熔点>260 °C(Solv: ethyl ether (60-29-7))
储存条件-20°C储存
溶解度DMSO : ≥ 34 mg/mL (40.06 mM)
形态Solid
颜色White to light yellow
929895-45-4价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/04/30 | HY-15594A | 929895-45-4 Phen-DC3 Trifluoromethanesulfonate | 929895-45-4 | 1mg | 600元 |
| 2024/04/30 | HY-15594A | 929895-45-4 Phen-DC3 Trifluoromethanesulfonate | 929895-45-4 | 5mg | 1035元 |
| 2024/04/30 | HY-15594A | 929895-45-4 Phen-DC3 Trifluoromethanesulfonate | 929895-45-4 | 10mg | 1800元 |
常见问题列表
生物活性
Phen-DC3 Trifluoromethanesulfonate 是一个 G4 特异性配体，可以抑制解旋酶 FANCJ 和 DinG 且 IC50s 值分别为 65±6 和 50±10 nM。靶点
IC50: 65±6 nM (G4 substrate, FANCJ helicase), 50±10 nM (G4 substrate, DinG helicases)
体外研究
In WT cells, a CEB1-WT array is rather stable but undergoes frequent rearrangements upon addition of 10 μM Phen-DC3 Trifluoromethanesulfonate (Phen-DC3). It is found that the c-Myc allele exhibits significant destabilization upon Phen-DC3 Trifluoromethanesulfonate treatment and PIF1 deletion. The CEB25-L111(T) array is stable in WT cells, it becomes unstable upon addition of Phen-DC3 Trifluoromethanesulfonate or deletion of PIF1. It is also highly destabilized in the presence of Phen-DC3 Trifluoromethanesulfonate or in the absence of PIF1. The CEB1-loop CEB25 allele remaines fully stable in both PIF1-treated and WT cells.