93076-89-2
![93076-89-2 结构式](/CAS/GIF/93076-89-2.gif)
基本信息
二乙酰基甘油激酶
化合物 T16709
二酰基甘油激酶5/DGK-Ε抗体
DAGK
DGKE
DGKI
DAGK4
DAGK7
DGK-θ
R59022
DKGI-I
DAG KINASE
常见问题列表
PKC
|
serotonin
|
diacylglycerol kinase 2.8 μM (IC 50 ) |
In the intact platelet, R 59-022 is able to interrupts thrombin-induced inositol lipid cycling at the level of diacylglycerol and leads to an elevation of protein kinase C activity.
R 59-022 (10 μM) potentiates aggregation, but not shape change induced by sub-maximal concentrations of thrombin. R59022 (10 μM) had no significant effect on the dose-response curve for the mobilization of intracellular Ca
2+
by thrombin in either the presence or the absence of extracellular Ca
2+
.
R 59-022, an inhibitor of filovirus entry, prevents the macropinocytic uptake of filoviral particles, inhibits entry mediated by multiple filovirus GPs, and blocks replicative EBOV growth. R 59-022 blocks entry of EBOV pseudotypes in a concentration-dependent manner (IC
50
: ~5 µM). R 59-022 dose-dependent decreases in entry by the VLPs harboring the EBOV GP (IC
50
: ~2 µM). R 59-022 (2-12 μM; 1 hour) can inhibit EBOV GP-mediated entry in multiple cell types. R 59-022 (5 µM; 30 minutes) blocks macropinocytosis in vero cells.