947669-91-2
947669-91-2 结构式
基本信息
WWL70 化学试剂
WWL 70,ABHD6抑制剂
4'-氨基甲酰基-[1,1'-联苯]-4-基 甲基(3-(吡啶-4-基)苄基)氨基甲酸酯
WWL 70
WWL70
WWL-70.
4-CARBAMOYL-[1,1-BIPHENYL]-4-YL METHYL(3-(PYRIDIN-4-YL)BENZYL)CARBAMATE
[4-(4-carbamoylphenyl)phenyl] N-methyl-N-[(3-pyridin-4-ylphenyl)methyl]carbamate
N-Methyl-N-[[3-(4-pyridinyl)phenyl]methyl]-4'-(aminocarbonyl)[1,1'-biphenyl]-4-ylcarbamicacidester
Carbamic acid, N-methyl-N-[[3-(4-pyridinyl)phenyl]methyl]-, 4'-(aminocarbonyl)[1,1'-biphenyl]-4-yl ester
物理化学性质
常见问题列表
IC50: 70 nM (ABHD6)
At 1 h after WWL70 (10 μM) treatment, 2-Arachidonoylglycerol (2-AG) is increased by 20% compare to untreated cells. At either 1 or 10 μM, WWL70 completely blocks the lipopolysaccharide (LPS)-induced increase of PGE 2 . The enhanced mRNA expression of mPGES-1 and mPGES-2 by LPS is also reduced by WWL70. The IC 50 of WWL70 to inhibit the PGE 2 biosynthesis is about 100 nM.
Although post-treatment with WWL70 at 5 mg/kg does not have any effect, treatment with WWL70 at 10 mg/kg improves the performance significantly. WWL70 treatment improves motor coordination of traumatic brain injury (TBI) mice in a concentration dependent manner. The latency to fall in animals treated with WWL70 at 5 mg/kg increases from 74.92±4.8 to 99.57±5.21 on day 3 (p<0.01) and from 87.32±4.42 to 100.14±3.56 on day 7 (p<0.05) post-injury when compare with the vehicle-TBI groups. At 10 mg/kg, WWL70 treatment improves motor coordination starting on day 1 post-injury. WWL70 treatment completely restores the ability of TBI mice to continuously alternate arms during Y maze exploration (69.67±4.98 %).