951322-11-5
951322-11-5 结构式
基本信息
Deformylflustrabromine hydrochloride
6-Bromo-2-(1,1-dimethyl-2-propen-1-yl)-N-methyl-1H-indole-3-ethanamine hydrochloride
常见问题列表
α 4 β 2 nAChR
Desformylflustrabromine hydrochloride is a selective agonist of α 4 β 2 neuronal nicotinic acetylcholine receptor (nAChR) with a pEC 50 of 6.48. ACh-induced currents are potentiated and inhibited by Desformylflustrabromine hydrochloride in the high sensitivity (HS) and low sensitivity (LS) isoform preparations, although Desformylflustrabromine hydrochloride displays a higher potency on the LS isoform (pEC 50 =6.4±0.2) compare with the HS isoform (pEC 50 =5.6±0.2). Desformylflustrabromine hydrochloride potentiates ACh-induced responses of wild-type receptors expressed using the HS isoform preparation maximally by 350±20%, which is similar to receptors expressed via the LS isoform preparation (350±30%).