952849-76-2
952849-76-2 结构式
基本信息
KKL-10
KKL 10
KKL10
5-bromo-N-(5-(p-tolyl)-1,3,4-oxadiazol-2-yl)thiophene-2-carboxamide
5-bromo-N-[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]thiophene-2-carboxamide
物理化学性质
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/08/19 | HY-101865 | 952849-76-2 KKL-10 | 952849-76-2 | 5mg | 1300元 |
| 2024/08/19 | HY-101865 | 952849-76-2 KKL-10 | 952849-76-2 | 10mg | 2080元 |
| 2024/08/19 | S0147 | 952849-76-2 KKL-10 | 952849-76-2 | 5mg | 1576.46元 |
常见问题列表
| Target | Value |
|
ribosome rescue
() |
The ribosome rescue inhibitor KKL-10 exhibits exceptional antimicrobial activity against both attenuated and fully virulent strains of F. tularensis . The minimum inhibitory concentration (MIC) against F. tularensis strain LVS and Schu S4 are 0.12 and 0.48 μg/mL, respectively. KKL-10 arrests intracellular growth of F. tularensis during all stages of infection. KKL-10 does not affect macrophage viability or function. KKL-10 produces cytotoxic effects of less than 5% at concentrations up to 17.5 μg/mL. The combination of IFN-γ stimulation and KKL-10 activity results in a reduction of the bacterial load by >99.9%. KKL-10 is also able to inhibit growth of F. tularensis inside eukaryotic cells and show no toxicity to HepG2 cells.