956901-32-9

中文名称 BETAMETHASONE HYDROCHLORIDE

英文名称 BetaMethasone (hydrochloride)

CAS 956901-32-9

分子式 C28H38ClFO7

分子量 541.049

MOL 文件 956901-32-9.mol

956901-32-9 结构式

基本信息物理化学性质常见问题列表

基本信息

中文别名

盐酸倍他米松

英文别名

BetaMethasone (hydrochloride)

物理化学性质

储存条件-20°C储存

溶解度Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

形态粉末

常见问题列表

生物活性

Betamethasone hydrochloride 是一种合成糖皮质激素，具有抗炎和免疫抑制活性。Betamethasone hydrochloride 可加速胎儿肺成熟并诱导基因表达和细胞凋亡。

体外研究

Betamethasone (0.1-1 μM; 12 h) induces gene expression in L929 cells.
Betamethasone (0.1-1 μM; 48 h) induces CEM C7 T-cells apoptosis.

体内研究

Betamethasone (0.48 mg; i.v.gtt for 48 h) decreases the hypercapnia-induced increase in CBF due to decreased cerebral vasodilatation. Betamethasone (0.05 ml (1 mg/L); topical injection) ameliorates spinal nerve transection induced mechanical allodynia and thermal hyperalgesia, and reduces the activation of NF-κB and elevation of TNFα and IL-1β, and induces the expression of IL-10 in the rats brain.

Animal Model:	Rambouillet-Colombia ewes bred on a single occasion are received hypercapnic challenges
Dosage:	0.48 mg
Administration:	Injected into the fetal jugular vein at a rate of 1 ml/h (10 μg betamethasone/h) and maintained over the next 48 h.
Result:	Decreased cerebral blood flow (CBF) in all brain regions measured except the hippocampus after 24 h of infusion. The reduction in CBF was diminished to about 25-30 % after 48 h of infusion.