95833-19-5

中文名称化合物 T23943

英文名称 DA 4643

CAS 95833-19-5

分子式 C12H15ClN6S

分子量 310.8

MOL 文件 95833-19-5.mol

95833-19-5 结构式

基本信息应用领域

基本信息

中文别名

化合物 T23943

英文别名

DA 4643
N-[3-[2-(diaminomethylideneamino)-1,3-thiazol-4-yl]phenyl]-N'-methylmethanimidamide

应用领域

用途一

DA 4643 is one of histamine H2-receptor antagonistic. Two histamine H2-receptor antagonists of the phenylformamidine type, mifentidine (N-isopropyl-N'-(4-1H-imidazol-4-yl-phenyl) formamidine dihydrochloride; I) and DA 4643 (N-methyl-N'-(3-(2-guanidinothiazol-4-yl)-phenyl) formamidine dihydrochloride; II), have been investigated by experimental physico-chemical studies and theoretical conformational analysis. Both mifentidine and DA 4643 interact with the histamine H2-receptor at the same site, utilizing in the binding process the same, or closely similar, receptor structural features.