96478-43-2

中文名称茚达酮

英文名称 Irindalone

CAS 96478-43-2

分子式 C24H29FN4O

分子量 408.51

MOL 文件 96478-43-2.mol

96478-43-2 结构式

基本信息物理化学性质安全数据常见问题列表

基本信息

中文别名

茚达酮

英文别名

Irindalone
Lu 21-?098
1-[2-[4-[(1R)-3β-(4-Fluorophenyl)-2,3-dihydro-1H-inden-1α-yl]-1-piperazinyl]ethyl]-2-imidazolidinone
2-Imidazolidinone, 1-[2-[4-[(1R,3S)-3-(4-fluorophenyl)-2,3-dihydro-1H-inden-1-yl]-1-piperazinyl]ethyl]-

物理化学性质

储存条件-20°C储存

溶解度溶于二甲基亚砜

安全数据

危险性符号(GHS)

GHS07

警示词警告

危险性描述H302-H315-H319-H335

防范说明P261-P305+P351+P338

常见问题列表

生物活性

Irindalone 是一种 5-羟色胺 (5-HT2) 拮抗剂。

靶点

5-HT ₂ Receptor

体外研究

Irindalone causes a concentration-related inhibition of serotonin-induced contractions and shifts the serotonin curve to the right. Irindalone is more potent in inhibiting the serotonin-induced contractions. Irindalone has a similar profile in vitro, with a high affinity for serotonin 5-HT ₂ receptors and about a 10 times lower affinity for α ₁ -adrenoceptors.

体内研究

Irindalone dose dependently lowers the blood pressure in spontaneously hypertensive rats (SHR) and renal hypertensive dogs.