96800-41-8
中文名称
DUP 105
英文名称
4-methylsulfinylphenyloxooxazolidinylmethylacetamide
CAS
96800-41-8
分子式
C13H16N2O4S
分子量
296.34
MOL 文件
96800-41-8.mol
更新日期
2023/03/17 20:03:06
96800-41-8 结构式
基本信息
中文别名
化合物DUP 105化合物 T11123
英文别名
DuP-1054-methylsulfinylphenyloxooxazolidinylmethylacetamide
(5S)-5-Acetylaminomethyl-3-(4-methylsulfinylphenyl)oxazolidin-2-one
N-[[(5S)-3-[4-(Methylsulfinyl)phenyl]-2-oxooxazolidin-5-yl]methyl]acetamide
(S)-N-<<3-<4(S)-(methylsulfinyl)phenyl>-2-oxo-5-oxazolidinyl>methyl>acetamide
Acetamide, N-[[(5S)-3-[4-(methylsulfinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]-
常见问题列表
生物活性
DuP 105 是一种可口服的恶唑烷酮类化合物，能够抗葛兰素阳性菌。体外研究
DuP 105 shows inhibitory activities against staphylococcal isolates and B. fragilis isolates with MIC 90 s of 4 to 16 μg/mL and 16 μg/mL. DuP 105 MICs for 50% of the 216 gram-positive isolates tested (MIC 50 s) range from 4.0 to 16 μg/mL.
体内研究
DuP 105 administered by either the oral or the parenteral route is protective against staphylococcal and streptococcal infections in mice with the 50% effective doses of 9 to 23 mg/kg.