99009-20-8

中文名称 NSC 366140 无结构图

英文名称 NSC 366140

CAS 99009-20-8

分子式 C19H21N5O3

分子量 367.4

MOL 文件 99009-20-8.mol

更新日期 2023/03/20 15:41:25

99009-20-8 结构式

基本信息物理化学性质图谱信息常见问题列表

基本信息

中文别名

NSC 366140 无结构图

英文别名

Pd 115934
NSC 366140
Pd 115,934
Brn 4211902
Pyrazoloacridine
N,N-Dimethyl-9-methoxy-5-nitropyrazolo(3,4,5-kl)acridine-2(6H)-propanamine
Pyrazolo(3,4,5-kl)acridine-2(6H)-propanamine, N,N-dimethyl-9-methoxy-5-nitro-
9-Methoxy-N,N-dimethyl-5-nitropyrazolo[3,4,5-kl]acridine-2(6H)-propane-1-amine
(3-(9-METHOXY-5-NITRO-6H-PYRAZOLO(3,4,5-KL)ACRIDIN-2-YL)-PROPYL)-DIMETHYL-AMINE
2,6-Dihydro-2-(3-dimethylaminopropyl)-9-methoxy-5-nitropyrazolo[3,4,5-kl]acridine

物理化学性质

沸点584.3±50.0 °C(Predicted)

密度1.38±0.1 g/cm3(Predicted)

储存条件-20°C储存

酸度系数(pKa)9.35±0.28(Predicted)

形态Solid

颜色Light brown to orange

图谱信息

NSC 366140 无结构图(99009-20-8)核磁图(¹HNMR)

常见问题列表

生物活性

Pyrazoloacridine (NSC 366140) 具有抗癌活性，抑制拓扑异构酶 1 和 2 的活性 (topoisomerases 1 and 2)。Pyrazoloacridine (NSC 366140) 对 K562 髓系白血病细胞中的 IC50 值为 1.25 μM (24 h)。

体外研究

Pyrazoloacridine (NSC 366140, PD 115934) exhibits IC ₅₀ values of 10.7 μM and 4.5 μM for oxic and hypoxic HCT-8 cells.
Pyrazoloacridine (NSC 366140, 2-4 μM) abolishes the catalytic activity of both topo I and topo II in vitro.
Pyrazoloacridine (NSC 366140) displays activity against cisplatin- and paclitaxel-resistant ovarian cancer.
Pyrazoloacridine (NSC 366140) has been shown to cause delayed DNA fragmentation in MCF-7 breast cancer cells.
Pyrazoloacridine (NSC 366140) induces apoptosis in P53-deficient Hep 3B human hepatoma cells.

Cell Cytotoxicity Assay

Cell Line:	K562 Myeloid Leukemia Cells.
Concentration:	0-500 μM.
Incubation Time:	1 h or 24 h.
Result:	When K562 cells were incubated with PA for 1 h and then plated in soft agar, an IC ₅₀ of -50 μM was observed. In contrast, when cells were incubated for 24 h with PA, the IC ₅₀ was 1.25 μM.