基本信息
中文别名
L-酵母氨酸 英文别名
saccharopineL-SACCHAROPINE
ω-N-(L-glutar-2-yl)-L-lysine
epsilon-N-(L-Glutar-2-yl)-L-lysine
N6-(L-1,3-dicarboxylpropyl)-L-lysine
N-(5-Amino-5-carboxypentyl)-L-glutamic acid
N-[(S)-5-Amino-5-carboxypentyl]-L-glutamic acid
N-[(5S)-5-Amino-5-carboxypentyl]-L-glutamic acid
L-Glutamic acid, N-[(5S)-5-amino-5-carboxypentyl]-
2-[(5-amino-5-carboxy-pentyl)amino]pentanedioic acid
物理化学性质
熔点257-259℃ (Decomposition)
比旋光度D23 +33.6° (c = 1 in 0.5N HCl)
沸点537.2±50.0 °C(Predicted)
密度1.333±0.06 g/cm3(Predicted)
储存条件−20°C
酸度系数(pKa)pK2 2.6; pK3 4.1; pK4 9.2; pK5 10.3(at 25℃)
常见问题列表
生物活性
Saccharopine (L-Saccharopine) 是赖氨酸的降解中间体，是一种线粒体毒素。赖氨酸-酮戊二酸还原酶将赖氨酸和 α-酮戊二酸转化为 Saccharopine。糖精脱氢酶将 Saccharopine 氧化为 α-氨基己酸酯半醛和谷氨酸。Saccharopine 通过破坏线粒体稳态而损害发育。体外研究
Saccharopine accumulation leads to mitochondrial damage and functional loss which is induced by saccharopine dehydrogenase (SDH) mutations of α-aminoadipate semialdehyde synthase (AASS)-1 in C. elegans .
体内研究
Saccharopine accumulation induces mitochondrial damage and progressive postnatal growth retardation in Aass mutant mice.