7Α,25-二羟基胆固醇
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- CAS号:
- 64907-22-8
- 英文名:
- 7α,25-dihydroxy Cholesterol
- 英文别名:
- 7Α;7α,25-OHC;Cholesterol Impurity 33;25-dihydroxycholesterol;5-Cholesten-3β,7α,25-triol;7α,25-dihydroxy Cholesterol;7-alpha,25-Dihydroxycholesterol;3β,7α,25-Trihydroxycholest-5-ene;3β,7α,25-Trihydroxycholest-5-ene;(3β,7α)-Cholest-5-ene-3,7,25-triol
- 中文名:
- 7Α,25-二羟基胆固醇
- 中文别名:
- 胆固醇杂质33;7Α,25-OHC;7Α,25-二羟基胆固醇;化合物7Α,25-DIHYDROXYCHOLESTEROL
- CBNumber:
- CB01235638
- 分子式:
- C27H46O3
- 分子量:
- 418.65
- MOL File:
- 64907-22-8.mol
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7Α,25-二羟基胆固醇化学性质
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沸点:
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548.5±35.0 °C(Predicted)
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密度:
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1.08±0.1 g/cm3(Predicted)
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储存条件:
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2-8°C
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溶解度:
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DMSO: soluble5mg/mL (clear solution)
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形态:
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powder
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酸度系数(pKa):
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14.11±0.70(Predicted)
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颜色:
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white to beige
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7Α,25-二羟基胆固醇性质、用途与生产工艺
7α, 25-dihydroxycholesterol (7α,25-OHC) 是一种孤儿 GPCR 受体 EBI2 (GPR183) 的有效选择性激动剂和内源性配体。7α, 25-dihydroxycholesterol 对激活 EBI2 有很强的作用 (EC50=140 pM; Kd=450 pM)。7α, 25-dihydroxycholesterol 可作为一种趋化因子，指导 B 细胞、T 细胞和树突状细胞的迁移。
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Human Endogenous Metabolite
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In vitro, 7α, 25-dihydroxycholesterol (7α,25-OHC) stimulates the migration of EBI2-expressing mouse B and T cells with half-maximum effective concentration values around 500 pM, but had no effect on EBI2-deficient cells.
EBI2-deficient B cells or normal B cells desensitized by 7α,25-Dihydroxycholesterol (1 μM; 1.5 hours) pre-treatment shows reduced homing to follicular areas of the spleen.
7Α,25-二羟基胆固醇
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| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-113962 | 7Α,25-二羟基胆固醇
7α,25-Dihydroxycholesterol | 64907-22-8 | 5mg | 3500元 |
| 2024/04/30 | HY-113962 | 7Α,25-二羟基胆固醇
7α,25-Dihydroxycholesterol | 64907-22-8 | 10mg | 4800元 |
64907-22-8, 7Α,25-二羟基胆固醇 相关搜索:
- 抑制剂
- 脂类
- 7Α,25-OHC
- 胆固醇杂质33
- 化合物7Α,25-DIHYDROXYCHOLESTEROL
- 7Α,25-二羟基胆固醇
- 64907-22-8
- Cholest-5-ene-3,7,25-triol, (3β,7α)-
- endogenous,response,oxysterols,Endogenous Metabolite,GPCR,EBI2/GPR183,ligand,7α,25 Dihydroxycholesterol,receptor,Inhibitor,immune,7α,25-Dihydroxycholesterol,migration,7α,25Dihydroxycholesterol,cells,inhibit
- 3β,7α,25-Trihydroxycholest-5-ene
- Cholesterol Impurity 33
- 7Α
- 7α,25-dihydroxy Cholesterol
- 7α,25-OHC
- (3β,7α)-Cholest-5-ene-3,7,25-triol
- 7Α,25-DIHYDROXYCHOLESTEROL;7Α;25-DIHYDROXYCHOLESTEROL
- 25-dihydroxycholesterol
- 5-Cholesten-3β,7α,25-triol
- 3β,7α,25-Trihydroxycholest-5-ene
- 7-alpha,25-Dihydroxycholesterol