136174-04-4

生物活性靶点体外研究体内研究

136174-04-4

CAS号:: 136174-04-4

英文名:: N-(1-azabicyclo(2.2.2)octan-3-yl)-2-chloro-5a,6,7,8,9,9a-hexahydrodibenzofuran-4-carboxamide

英文别名:: RG 12915,RG12915;N-(1-azabicyclo(2.2.2)octan-3-yl)-2-chloro-5a,6,7,8,9,9a-hexahydrodibenzofuran-4-carboxamide;4-Dibenzofurancarboxamide, N-(3S)-1-azabicyclo(2.2.2)oct-3-yl-2-chloro-5A,6,7,8,9,9A-hexahydro-, (5as,9as)-;4-Dibenzofurancarboxamide, N-(3S)-1-azabicyclo[2.2.2]oct-3-yl-2-chloro-5a,6,7,8,9,9a-hexahydro-, (5aS,9aS)- (9CI);(5As-(4(R*),5aalpha,9aalpha))-N-1-azabicyclo(2.2.2)oct-3-yl-2-chloro-5A,6,7,8,9,9A-hexahydro-4-dibenzofurancarboxamide;4-Dibenzofurancarboxamide, N-1-azabicyclo(2.2.2)oct-3-yl-2-chloro-5A,6,7,8,9,9A-hexahydro-, (5as-(4(R*),5aalpha,9aalpha))-

中文名:: 136174-04-4

中文别名:: 化合物 T12716

CBNumber:: CB01355653

分子式:: C20H25ClN2O2

分子量:: 360.88

MOL File:: 136174-04-4.mol

化学性质安全信息用途供应商 7

136174-04-4化学性质

沸点:: 462.6±45.0 °C(Predicted)

密度:: 1.31±0.1 g/cm3(Predicted)

储存条件:: Store at -20°C

溶解度:: Soluble in DMSO

酸度系数(pKa):: 13.83±0.20(Predicted)

安全信息

136174-04-4性质、用途与生产工艺

生物活性

RG-12915 是一种选择性的 5-HT3 拮抗剂，IC50 值为 0.16 nM。

RG 12915 is a potent and selective displacer of binding of 5-hydroxytryptamine (5-HT3) binding sites (IC ₅₀ value = 0.16 nM), whereas failing to displace binding of ligands for the alpha-1, alpha-2 and beta adrenergic, 5-HT1 or 5-HT2 or cholinergic-muscarinic sites with IC ₅₀ values less than 1 μM.

体内研究

RG 12915 has a lower ED ₅₀ value (0.004 mg/kg) for attenuating cisplatin-induced emetic episodes in the ferret. RG 12915 (1 mg/kg, p.o.) is highly protective against cisplatin-induced emesis in the dog. RG 12915 has no significant gastroprokinetic activity in the same species.

136174-04-4 上下游产品信息

上游原料

下游产品

136174-04-4 生产厂家

全球有 7家供应商 136174-04-4国内生产厂家

供应商	联系电话	电子邮件	国家	产品数	优势度
MedChemexpress LLC	021-58955995	sales@medchemexpress.cn	美国	4863	58
范德(北京)生物科技有限责任公司	15911056312	liming@bio-fount.com	中国	9730	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	美国	19892	58
成都超九八生物科技有限公司	13348960310 13348960310	3003867561@qq.com	中国	10011	58
天津普西唐生物医药科技有限公司	010-60605840 15801484223	psaitong@jm-bio.com	中国	29778	58
TargetMol中国（陶术生物）	4008200310	marketing@tsbiochem.com	中国	24017	58

136174-04-4, 136174-04-4 相关搜索:

化合物 T12716
136174-04-4
RG 12915,RG12915
4-Dibenzofurancarboxamide, N-(3S)-1-azabicyclo[2.2.2]oct-3-yl-2-chloro-5a,6,7,8,9,9a-hexahydro-, (5aS,9aS)- (9CI)
4-Dibenzofurancarboxamide, N-1-azabicyclo(2.2.2)oct-3-yl-2-chloro-5A,6,7,8,9,9A-hexahydro-, (5as-(4(R*),5aalpha,9aalpha))-
4-Dibenzofurancarboxamide, N-(3S)-1-azabicyclo(2.2.2)oct-3-yl-2-chloro-5A,6,7,8,9,9A-hexahydro-, (5as,9as)-
(5As-(4(R*),5aalpha,9aalpha))-N-1-azabicyclo(2.2.2)oct-3-yl-2-chloro-5A,6,7,8,9,9A-hexahydro-4-dibenzofurancarboxamide
N-(1-azabicyclo(2.2.2)octan-3-yl)-2-chloro-5a,6,7,8,9,9a-hexahydrodibenzofuran-4-carboxamide