188048-45-5
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- CAS号:
- 188048-45-5
- 英文名:
- WS 75624 B
- 英文别名:
- WS 75624 B;(±)-WS-75624B,(±)WS75624B,(±) WS75624B;2-Pyridinecarboxylic acid, 6-[2-(6-hydroxyheptyl)-4-thiazolyl]-4,5-dimethoxy-
- 中文名:
- 188048-45-5
- 中文别名:
- 化合物 T13471;(±)-WS75624B
- CBNumber:
- CB01386457
- 分子式:
- C18H24N2O5S
- 分子量:
- 380.46
- MOL File:
- 188048-45-5.mol
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188048-45-5化学性质
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沸点:
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538.5±50.0 °C(Predicted)
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密度:
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1.249±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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酸度系数(pKa):
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3.47±0.10(Predicted)
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188048-45-5性质、用途与生产工艺
(±)-WS75624B 是一种内皮素转化酶 (ECE) 抑制剂，IC50 为 0.03 μg/mL。
Endothelin converting enzyme (ECE) inhibitors, WS75624A and (±)-WS75624B, have been isolated from the fermentation broth of
Saccharothrix
sp. No. 75624. WS75624A and (±)-WS75624B show highly potent ECE inhibitory activity, and both have IC
50
s of 0.03 μg/mL. WS75624A and (±)-WS75624B also show other metalloprotease (collagenase and neutral endopeptidase) inhibitory activity with IC
50
s of 1 μg/mL. (±)-WS75624B markedly inhibits ECE activity with an IC
50
value of 0.03 μg/mL, while it weakly inhibit collagenase and NEP activities with IC
50
s of 1.0 μg/mL and 1.25 μg/mL, respectively.
(±)-WS75624B inhibits big endothelin-induced pressor effect when administered to SD rat intravenously with big ET-1. WS75624 B (30 mg/kg) markedly attenuates the hypertensive effect of big ET-1 (1 nmol/kg,iv) the inhibiting the conversion of big ET-1 to ET-1.
188048-45-5
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188048-45-5, 188048-45-5 相关搜索:
- 化合物 T13471
- (±)-WS75624B
- 188048-45-5
- (±)-WS-75624B,(±)WS75624B,(±) WS75624B
- 2-Pyridinecarboxylic acid, 6-[2-(6-hydroxyheptyl)-4-thiazolyl]-4,5-dimethoxy-
- WS 75624 B