2-羟基阿托伐他汀
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- CAS号:
- 214217-86-4
- 英文名:
- ORTHO-HYDROXY ATORVASTATIN
- 英文别名:
- PD 152873;BMS 243887-01;2-Hydroxyatorvastatin;ORTHO-HYDROXY ATORVASTATIN;Atorvastatin 2-Hydroxy SodiuM;Atorvastatin 2-Hydroxy Calcium;o-Hydroxyatorvastatin Disodium Salt;2-Hydroxy Atorvastatin Disodium salt;2-Hydroxy Atorvastatin Dihydrate Monosodium Salt;o-Hydroxy Atorvastatin
DISCONTINUED, offer stable alternates only
- 中文名:
- 2-羟基阿托伐他汀
- 中文别名:
- 2-羟基阿托伐他汀;阿托伐他汀2-羟基钠;2-羟基阿托伐他汀二水一钠盐
- CBNumber:
- CB01516070
- 分子式:
- C33H35FN2O6
- 分子量:
- 574.64
- MOL File:
- 214217-86-4.mol
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2-羟基阿托伐他汀化学性质
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熔点:
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132-134°C
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沸点:
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741.9±60.0 °C(Predicted)
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密度:
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1.27
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储存条件:
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-20°C Freezer
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溶解度:
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Methanol (Slightly)
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酸度系数(pKa):
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4.29±0.10(Predicted)
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形态:
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Solid
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颜色:
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Off-White
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稳定性:
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Hygroscopic
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CAS 数据库:
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214217-86-4
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2-羟基阿托伐他汀性质、用途与生产工艺
阿托伐他汀为他汀类血脂调节药,属HMG-CoA还原酶抑制剂前体。口服吸收后的水解产物在体内竞争性地抑制胆固醇合成过程中的限速酶,使胆固醇的合成减少,低密度脂蛋白受体合成增加,使血胆固醇和低密度脂蛋白胆固醇水平降低,中度降低血清甘油三酯水平和增高血高密度脂蛋白水平。适用于治疗高胆固醇血症和混合型高脂血症,可用于冠心病和脑中风的防治。2-羟基阿托伐他汀为阿托伐他汀的代谢产物。阿托伐他汀在人体内主要由细胞色素P450酶代谢为2-羟基阿托伐他汀(ortho-hydroxyatorvastatin,o-OAT)和4-羟基阿托伐他汀(para-hydroxyatorvastatin,p-OAT)。2-羟基阿托伐他汀和p-OAT占总体抑制活性的70%。同其他他汀类化合物一样,阿托伐他汀、2-羟基阿托伐他汀和p-阿托伐他汀结构中含有羟基羧酸结构,无论在体内和体外均能脱水关环形成内酯,并且,该体内内酯代谢物在体外也易于水解转化为羟基羧酸,因而,羟基羧酸浓度测定易受影响不准确。
2-羟基阿托伐他汀
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214217-86-4, 2-羟基阿托伐他汀 相关搜索:
- Pharmaceuticals
- Metabolites & Impurities
- Intermediates & Fine Chemicals
- Chiral Reagents
- Aromatics
- Metabolites
- Isotope Labeled Compounds
- 合成有机化合物配体
- 标准品
- C33H35FN2O6
- C33H28D5FN2Na2O6
- C33H38FN2NaO8
- 2-羟基阿托伐他汀二水一钠盐
- 2-羟基阿托伐他汀
- 阿托伐他汀2-羟基钠
- 214217-86-4
- 2-Hydroxy Atorvastatin bis sodium saltQ: What is
2-Hydroxy Atorvastatin bis sodium salt Q: What is the CAS Number of
2-Hydroxy Atorvastatin bis sodium salt Q: What is the storage condition of
2-Hydroxy Atorvastatin bis sodium salt Q: What are the applications of
2-Hydroxy Atorvastatin bis sodium salt
- o-Hydroxy Atorvastatin
DISCONTINUED, offer stable alternates only
- 1H-Pyrrole-1-heptanoic acid, 2-(4-fluorophenyl)-β,δ-dihydroxy-4-[[(2-hydroxyphenyl)amino]carbonyl]-5-(1-methylethyl)-3-phenyl-, (βR,δR)-
- Atorvastatin 2-Hydroxy Calcium
- (3R,5R)-7-(2-(4-Fluorophenyl)-4-(2-hydroxyphenylcarbamoyl)-5-isopropyl-3-phenyl-1H-pyrrol-1-yl
- 2-Hydroxy Atorvastatin Disodium salt
- Atorvastatin 2-Hydroxy SodiuM
- (3R,5R)-7-(2-(4-fluorophenyl)-4-(2-hydroxyphenylcarbaMoyl)-5-isopropyl-3-phenyl-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoic acid
- 2-Hydroxyatorvastatin
- (betaR,deltaR)-2-(4-Fluorophenyl)-beta,delta-dihydroxy-4-[[(2-hydroxyphenyl)amino]carbonyl]-5-(1-methylethyl)-3-phenyl-1H-pyrrole-1-heptanoic acid
- 2-Hydroxy Atorvastatin Dihydrate Monosodium Salt
- PD 152873
- BMS 243887-01
- (R,dR)-2-(4-fluorophenyl)-,d-dihydroxy-4-[[(2-hydroxyphenyl)amino]carbonyl]-5-(1-methylethyl)-3-phenyl-1H-pyrrole-1-heptanoic Acid Dihydrate Monosodium Salt
- o-Hydroxyatorvastatin Disodium Salt
- (R,dR)-2-(4-fluorophenyl)-,d-dihydroxy-4-[[(2-hydroxyphenyl)amino]carbonyl]-5-(1-methylethyl)-3-(phenyl-d5)-1H-pyrrole-1-heptanoic Acid Disodium Salt
- ORTHO-HYDROXY ATORVASTATIN